BIMS 803
Fundamental Immunology
(Also listed as MICR 803)
Time:  MWF, 10:30 - 12:00
Place:  Room 117, Jordan Hall

Micro/BIMS 803 assumes a basic background in immunology and will provide detailed coverage of topics in cellular and molecular immunology.  The class will consider characteristics and regulation of immune responses but particular emphasis will be placed on experimental approaches to study the immune system.  Lectures and readings will provide background material but will focus on experimental approaches as well as discussions of the recent literature.  Thus, it will be important that class members read assigned background material before class.  The course is appropriate for graduate students and clinical fellows.  A previous introductory course in immunology is strongly recommended and permission of the course director is required to register.

Required text:
Cellular and Molecular Immunology.  Abul K. Abbasa, Andrew H. Lichtman, and Shiv Pillai.  Sixth Edition.  Saunders-Elsevier Publishing.

Class Web Site: https://toolkit.itc.virginia.edu/cgi-local/tk/UVa_CLAS_2008_Spring_MICR803-1

FUNDAMENTAL IMMUNOLOGY - SPRING 2008
 

Date

Lecturer

Topic

 

 

 

BLOCK 1 - LYMPHOCYTE ANTIGEN RECEPTORS AND LYMPHOID DEVELOPMENT

Jan 16

Tung

Anatomy of Immune Responses

Jan 17*

Lannigan

Flow Cytometry

Jan 18

Lorenz

BCR and TCR Structure

Jan 21

Bender

Ig and Tcr gene structure and generation of diversity

Jan 23

Bender

Regulation and timing of VDJ recombination

Jan 25

Bender

B cell Development

Jan 28

Bender

Checkpoints and Selection of the B Cell Repertoire

Feb 1**

Engelhard

Structure of Antigens Recognized by T cells

Feb 4**

Engelhard

Continuation

Feb 6

Lorenz

T Cell Development

Feb 8

Lorenz

Role of the Thymus in Selection of the T Cell Repertoire

 

 

 

BLOCK 2 - CELL ACTIVATION, INTERACTIONS AND EFFECTOR MECHANIMS

Feb 11

Engelhard

Ag Processing and Presentation

Feb 13

Engelhard

Continuation

Feb 15

Engelhard

APC and Cellular Interactions

Feb 18

Mullins

Trafficking

Feb 20

Mullins

Induction of primary responses and T cell memory

Feb 22

Ravi

T cell activation

Feb 25

Ravi

B cell act

Feb 27

Ravi

Homeostasis I

Feb 29

Ravi

Homeostasis II

Mar 1 - 9

 

SPRING BREAK

 

 

 

BLOCK 3 - IMMUNE EFFECTOR MECHANISMS

Mar 10

Braciale

CD4 differentiation

Mar 12

Braciale

T cell effector mechanisms

Mar 14

Braciale

T cell effector mechanisms

Mar 17

Bender

Peripheral B cell subsets and maturation of the Ab response

Mar 19

Erickson

B cell memory and plasma cells

Mar 21

Taylor

Complement

Mar 24

Mehrad/Taylor

Inflammation

Mar 26

Mehrad

Pattern Recognition and Toll-like Receptors

Mar 28

Brown

NK Cells

Mar 31

Brown

NK Cells

Apr 2

Ernst

Development of Mucosal Immunity

 

BLOCK 4 - IMMUNE EFFECTOR MECHANISMS AND THEIR CONSEQUENCES

Apr 4

Petri

Immunity to Extracellular Bacteria and Evasion Strategies

Apr 7

Petri

Immunity to Protozoan Parasites and Evasion Strategies

Apr 9

Woodfolk

Immunology and Biology of IgE/Th2

Apr 11

Hahn

Immunity to Viruses and Intracellular Bacteria and Evasion Strategies

Apr 14

Hahn

Immunity to Viruses and Intracellular Bacteria and Evasion Strategies

Apr 16

Braciale

Vaccines

Apr 18

Bullock

Transplantation

Apr 21

Bullock

Tumor Immunology

Apr 23

Tung

Tolerance

Apr 25

Tung

Autoimmunity

Apr 28

Tung

Continuation


  * Please note this lecture will be given on a Thursday.

** Please note that these lectures will be included on Exam II, not Exam I. 

There will be four (4) exams each valued at 10 points per lecture.  Exam Times and location to be negotiated:

                         Last Lecture                   Exam Date
Block 1            Feb 8                                 Feb 11 or 12
Block 2            Feb 29                               Mar 12 or 13
Block 3            Apr 2                                Apr 4 or 7
Block 4           Apr 28                               May 2, 5 or 6