University of Virginia Health System

Staff Update

August 2007

Medication Induced Weight Gain

Anne Wolf, MS, RD

People gain weight for many reasons but one of the least diagnosed causes of weight gain is medication use.  The mechanism of action of drug induced weight gain varies by medication type but includes increasing one's appetite, causing nutrient cravings (such as carbohydrate or fat cravings) or slowing metabolism. While studies show a growing number of commonly prescribed medications - for conditions ranging from depression to high blood pressure -- may cause weight gain, there may be alternatives that don't have that effect, or may not cause as much weight gain as others.   Below is a chart of medications that are recognized as contributing to weight gain.

It is important that our participants understand that they should not stop the medication themselves even if they suspect it is causing weight gain. They must first discuss their concerns with their doctor and work with their physician if medications are to be changed.  The medication chart or a PDF of a recently published, peer-reviewed research article can be given to our study participants so they can share the information with their doctor.

In some cases, medications cannot be replaced-alternative medications are not available or as effective for the currently used medication.  If this is the case, the participant will need to be more vigilant about their lifestyle choices. 

Table 1. Medications associated with Weight Gain*

- 

*Adapted from: Leslie W.S, et al. Review: Weight gain as an adverse effect of some commonly prescribed drugs: A Systemmatic Review. J Q Med 2007; 100:395-404. The table in the paper provides specifics about the studies and length of follow up.

Leslie, et al. Meds and Wt Gain

HIC# 11143