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15 March 2006

The Science of Stem Cells

Lawrence Goldstein, Cellular and Mollecular Medicine, University of California, San Diego

Stem cell research is important and controversial science these days, promising great advances in the treatment and cure of major diseases. What is stem cell science all about, and what role do political realities and ethical concerns play in researchers' quests for scientific breakthroughs?


Dr. Lawrence S.B. Goldstein is Professor of Cellular and Molecular Medicine at the University of California, San Diego, School of Medicine. He  is also an Investigator with the Howard Hughes Medical Institute. He receives grant funding from the NIH, the Johns Hopkins ALS Center, the  Hereditary Disease Foundation, the Ellison Medical Foundation, and has over 100 publications.
            Dr. Goldstein received his B.A. in biology and genetics from UCSD in 1976 and his Ph.D. in genetics from the University of Washington, Seattle  in 1980. He did postdoctoral research at the University of Colorado at Boulder from 1980-1983 and the Massachusetts Institute of Technology in 1983 and 1984. He was Assistant, Associate and Full Professor at Harvard University in the Department of Cellular and Developmental Biology from 1984 to 1993 and moved to UCSD and HHMI in 1993.
            His awards include a Senior Scholar Award from the Ellison Medical Foundation, an American Cancer Society Faculty Research Award, and the Loeb Chair in Natural Sciences when he was at Harvard University. His  research is focused on understanding the molecular mechanisms of intracellular movement in neurons and the role of transport dysfunction in neurodegenerative diseases. His lab provided the first molecular descriptions of kinesin structure and organization, and has recently discovered important links between transport processes and diseases such as Alzheimers Disease and Huntingtons Disease.
            Dr. Goldstein has also had an active role in National Science policy. He has served on many public science advisory committees, has written, spoken and been interviewed on numerous occasions on science issues by print and broadcast media, and has testified on a number of occasions in the U.S. House of Representatives and the Senate about NIH funding and stem cell research. As a cofounder and consultant of the biotechnology company Cytokinetics he has also had an active role in private industry.