Sickle cell
(Drepanocyte)
Peripheral blood smear, Wright-Giemsa stain, 400x
Description:
The classic sickle cell is sickle or crescent-shaped and often hyperchromic without central palor. Other forms seen are holly leaf- or boat- shaped.
Pathobiology:
Results from polymerization of abnormal hemoglobin.
Differential Diagnosis:
- Sickle cell (SS) disease
- Hemoglobin SC disease
- Hemoglobin SD disease
- Hemoglobin S-beta thalassemia
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Charles
E.
Hess,
M.D.,FACP [more information]
Professor of Internal Medicine
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