Pappenheimer Bodies
Peripheral blood smear, Iron stain, 1000x
Peripheral blood smear, Wright-Giemsa stain, 1000x
Description:
Fine basophilic red cell inclusions, usually clustered, near the inner cell membrane. A red cell containing Pappenheimer bodies is referred to as a siderocyte on iron stain.
Pathobiology:
Composed of aggregates of ferritin (hemosiderin) with a variable component of ribosomes and mitochondrial remnants.
Differential diagnosis:
- Asplenia and hyposplenia
- Megaloblastic anemias
- Myelodysplastic syndromes with dyserythropoiesis
- Thalassemias
- Lead poisoning (basophilic stippling usually prominent)
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Charles
E.
Hess,
M.D.,FACP
Professor of Internal Medicine |
| Department of Medicine Division of Hematology/Oncology |
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| M.D. Degree: | University of Virginia, 1959 | |
| Residency: | Internal Medicine, University of Virginia | |
| Fellowship: | Hematology, University of Virginia | |
| Certification: |
Internal Medicine
Hematology |
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| Research Interests: | Hematologic malignancies, splenomegaly | |
| Department Web Site: | http://www.healthsystem.vir ginia.edu/internet/internal/ |
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| Phone: | (434) 924-2572 | |