Chronic Leukemias
WHO Classification of Chronic Leukemias (with modification):
B cell chronic lymphocytic leukemias (CLL)
This subset represents 90% or more of all chronic lymphocytic leukemias.
- Small B cell chronic lymphocytic leukemia (CLL, B-CLL))
- Mantle cell leukemia (MCL)
- Hairy cell leukemia (HCL)
- Prolymphocytic B cell leukemia (B-PLL)
- Leukemic phase of splenic lymphoma with villous lymphocytes (SLVL)
- Leukemic phase of splenic marginal zone lymphoma (MZL)
- Leukemic phase of lymphoplasmacytic lymphoma (LPL) including Waldentrom's macroglobulinemia (WM)
- Leukemic phase of follicular lymphoma (FL)
T and NK cell chronic lymphocytic leukemias
- Large granular lymphocyte (LGL) syndrome (leukemia)
- Leukemic phase of mycosis fungoides (MF) and Sezary's syndrome (SS)
- Prolymphocytic T cell leukemia (T-PLL)
- Small T cell chronic lymphocytic leukemia (T-CLL)
Other chronic leukemias
- Chronic myelocytic leukemia- classified under "myeloproliferative disorders"
- Chronic myelomonocytic leukemia- usually classified under "myelodysplastic syndromes" because dysplasia of the other cell lines is frequently present.
General References:
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Bennett JM, Catovsky D, Daniel MT, et al: Proposals for the classification of chronic (mature) B and T lymphoid leukemias. J Clin Pathol 42:567, 1989
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Jaffe ES, Harris NL, Stein H, Vardiman JW (Eds). World health organization classification of tumours. Pathology and genetics of tumours of hematopoietic and lymphoid tissues. IRAC Press: Lyon 2001
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Charles
E.
Hess,
M.D.,FACP [more information]
Professor of Internal Medicine
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