Sickle cell
(Drepanocyte)
Peripheral blood smear, Wright-Giemsa stain, 400x
Description:
The classic sickle cell is sickle or crescent-shaped and often hyperchromic without central palor. Other forms seen are holly leaf- or boat- shaped.
Pathobiology:
Results from polymerization of abnormal hemoglobin.
Differential Diagnosis:
- Sickle cell (SS) disease
- Hemoglobin SC disease
- Hemoglobin SD disease
- Hemoglobin S-beta thalassemia
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Charles
E.
Hess,
M.D.,FACP
Professor of Internal Medicine |
| Department of Medicine Division of Hematology/Oncology |
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| M.D. Degree: | University of Virginia, 1959 | |
| Residency: | Internal Medicine, University of Virginia | |
| Fellowship: | Hematology, University of Virginia | |
| Certification: |
Internal Medicine
Hematology |
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| Research Interests: | Hematologic malignancies, splenomegaly | |
| Department Web Site: | http://www.healthsystem.vir ginia.edu/internet/internal/ |
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| Phone: | (434) 924-2572 | |