Pappenheimer Bodies
Peripheral blood smear, Iron stain, 1000x
Peripheral blood smear, Wright-Giemsa stain, 1000x
Description:
Fine basophilic red cell inclusions, usually clustered, near the inner cell membrane. A red cell containing Pappenheimer bodies is referred to as a siderocyte on iron stain.
Pathobiology:
Composed of aggregates of ferritin (hemosiderin) with a variable component of ribosomes and mitochondrial remnants.
Differential diagnosis:
- Asplenia and hyposplenia
- Megaloblastic anemias
- Myelodysplastic syndromes with dyserythropoiesis
- Thalassemias
- Lead poisoning (basophilic stippling usually prominent)
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Charles
E.
Hess,
M.D.,FACP [more information]
Professor of Internal Medicine
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