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Ying Wang, a Biochemistry Ph.D student in the Egelman Lab, has received the following award: Association of Women in Science (AWIS) Educational Foundation Citation of Merit. Project Title for the Award: Electron Microscopic Studies of Two Classes of Helical Polymers: Filamentous Bacteriophages & Type 3 Secretion System Needles. Research Statement: "Many biological molecules assemble into helical polymers. In this Electron Microscopic study, Iterative Helical Real Space Reconstruction (IHRSR) approach will be used to study the three-dimensional (3D) structures of two representative classes of helical polymers, filamentous bacteriophages and Type 3 secretion system (T3SS) needles. These two classes of helical polymers are related by, among other things, the polymorphism of the structure, according to previous literature and my preliminary data. The long-term goal of this project is to understand how the structures of these helical polymers are related to their function and activities." Related Publications: Journal of Molecular Biology and Structure. Previous Education: B.S., Biology, Fudan University Return to TOP |
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Research Statement: "Research has shown that low voltage activated (LVA) T-type calcium channels in the thalamus of the brain play a role in seizures related to Childhood Absence Epilepsy (CAE). Further, in patients with CAE, these T-type calcium channels may have mutations within their DNA sequence. These mutations, known as single nucleotide polymorphisms (SNPs), are defined as DNA sequence variations that occur when a single nucleotide (A, T, C, or G) in the genome sequence is altered. Joel and Nick’s project introduced mutations discovered in a calcium channel genes of patients afflicted with CAE in order to study the effects of these mutations on channel behavior." Additional Honors: For 2008, Joel has also received a Predoctoral Fellowship from the Epilepsy Foundation and a Grant-in-Aid of Research Award from Sigma Xi.
Previous Education: B.S., Biochemistry; |
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 Patrick Martin, Ph.D., has recently been selected as a recipient of one of the ten prestigious UNCF/MERCK Fellowships awarded for 2004 (http://www.uncf.org/merck/ ). Patrick received his Ph.D. from the Cell Biology graduate program of the University of Virginia and was a former trainnee under National Institutes of Health institutional training awards for Cell and Molecular Biology, as well as for Biotechnology. Patrick is currently a Postdoctoral Fellow in the Department of Pathology at the University of Virginia, working with Dr. Isa Hussaini. His research goals are to understand the regulatory role of the mTOR signaling pathway during malignant brain tumor formation. Malignant brain tumors are extremely aggressive tumors, which characteristically invade inoperable portions of the brain and are often resistant to chemotherapy and radiotherapy. Specifically, he is interested in identifying molecular mechanisms that mediate chemoresistance and invasion in malignant brain tumors. Another major focus of his fellowship award is to design and test novel small chemical inhibitors that prevent brain tumor growth and invasion. |
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 Sarah Mackinnon, a graduate student in Biophysics, has received a National Science Foundation (NSF) three-year fellowship. Her proposal is titled, "Conformational Change in Fusion Peptide Promotes Pore Formation."
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 Michael Davis, graduate student in Biochemistry and Molecular Genetics, recently returned from a Federation of American Societies for Experimental Biology (FASEB) conference with a First Place Biochemical Journal Poster Prize for the best graduate student poster. Michael's poster was entitled "Lysophospholipids and Related Bioactive Lipids in Biology and Diseases". This conference which was entitled "Lysophospholipids and Related Lipids in Biology and Diseases", was held June 28-July 3, 2003 and featured 63 posters. |
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