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Example Syllabus for |
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BIMS 808 Dr.'s Adler, Bauerle, Burke, Christman, Kadner, Pearson·White, and Smith Course Coordinator: 9:00·10:15 M W F Room 117 Jordan Hall Each professor will assign readings. There will be four exams covering the following sections: 1. Procaryotic genetics 2. Yeast genetics 3. Functional genomics and Drosophila genetics 4. Mammalian genetics
All exams will be given over weekends at the dates announced by respective professors (close to the end of the sections). The professor will explain the format for each exam. Procaryotic Genetics Dr. Bauerle 19 DNA repair and mutagenesis 22 DNA repair and mutagenesis Dr. Kadner 26 Transposons and genome evolution Dr. Bauerle 29 Gene transfer and genetic analysis 31 Gene transfer and genetic analysis Dr. Kadner Feb 2 Homologous recombination 5 Site-specific recombination
Yeast Genetics
Dr. Christman
7 Working with yeast: What's so awesome? 9 Performing a genetic screen and cloning the genes identified 12 Surgical manipulation of the genome 14 Genetic redundancy 16 Cell type determination 19 Cell cycle regulation of mitotic events
Dr. Burke
21 Genetic Interactions: Classical Genetics. Getting it done the Old Fashioned Way 23 Genetic Interactions: The Big Four and the Beauty of Plasmids 26 Genetic Interactions: Two-hybrid and Other Tricks of the Trade
Dr. Smith
28 Classical Jazz: Genetic dissection of the galactose pathway Mar 2 Romantic Jazz: Regulation of GAL gene transcription 5 Modern Jazz: Complications of GAL control at the molecular level
Functional Genomics
Dr. Smith
7 “The Genome": Assembling and using complete DNA sequences 9 "Data Mining": Characteristics and comparisons of complete genomes 12 Spring Break 14 Spring Break 16 Spring Break 19 "Genomic Scale": Bar coding; genetic footprinting 21 "Massively Parallel": DNA microarray analysis 23 "Proteomics": Genomic scale protein-protein interactions
Drosophila Genetics
Dr. Adler
26 Introduction to Drosophila Biology 28 Drosophila Genetics & Cytogenetics, classical genetics & genome project 30 Mutations and genetic screens, P-element biology, Apr2 P-elements: germ line transformation, mutagenesis and enhancer trapping 4 Directed expression of genes in Drosophila, RNAi 6 The construction and use of genetic mosaics
Human Genetics Dr. Burke
9 Transmission genetics and chromosomes in humans 11 Mapping human genes: genetic maps and physical maps 13 Integrating the physical and genetic maps. The genome project 16 Positional cloning
Mouse Genetics Dr. Pearson-White
18 Mouse genome, inbred strains, strategies 20 Directed gene expression or ablation, experimental strategies 23 X inactivation and imprinting, studies in mice 25 Transgenic mice 27 Gene Replacement techniques, findings 30 Gene Replacement techniques, recent |