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First Meeting will be Thursday August 28 at 11:30. Small conference room 4th floor Jordan
For further information, please contact Robert Nakamoto, Rm 4-55 Jordan Hall, 2-0279, rkn3c@virginia.edu
Two 1 1/2 hours sessions per week at a time to be announced
Schedule number: 63968
Prerequisites: BIMS 503, Macromolecular Structure and Function and BIMS 812, Cell Structure and Function; recommended BIOP/PHY 506 Experimental Approaches in Molecular Physiology and Biophysics
Instructors: Michael Wiener, Lukas Tamm, Robert Nakamoto, Marwan Al-Shawi, Eduardo Perozo, and Gabor Szabo
This course will be an in depth assessment of the structure and function of biological membranes. In addition to lectures, directed discussions of papers from the literature will be used. The main topics of the course are: (1) membrane and membrane protein structure, (2) lipid-protein interactions, (3) bioenergetics and transmembrane transport mechanisms, and (4) ion channels and their regulation. Emphasis will be placed on biophysical approaches in these areas. The primary literature will be the main source of reading. Students will be responsible for presentation of summaries of each assigned paper and discussions of the significance of the papers. Grading will be based on participation in these discussions, a final paper which will be written in the format of a grant proposal and an oral presentation of the proposal.
Michael Wiener
1. 9/2: Properties and structure of lipid bilayers: the hydrophobic effect and the fluid mosaic model.
2. 9/4: Properties and structure of lipid bilayers: structural analysis of bilayers
3. 9/9: Structure of membrane proteins: X-ray crystallography
Lukas Tamm
4. 9/11: Lipid-protein interactions: peptides with lipid bilayers
5. 9/16: Lipid-protein interactions: fusion peptides and membrane fusion
6. 9/18: Lipid-protein interactions: penetration of membranes by toxins
7. 9/23: Lipid-protein interactions: insertion and folding of membrane proteins
Robert Nakamoto
8. 9/25: Bioenergetics and the transport of ions
9. 9/30: Redox and light driven pumps
10. 10/2: Outer membrane transporters (Michael Wiener)
11. 10/7: ABC transporters (Marwan Al-Shawi)
12. 10/9: F and V-ATPases
13. 10/14: P-type ATPases, and other transporters
10/16: No class
Eduardo Perozo
14. 10/21: Permeation and selectivity
15. 10/23: Voltage-dependent gating
16. 10/28: Ligand-dependent gating
17. 10/30: Opening and closing the pore
Gabor Szabo
18. 11/4: Regulation of channel function
19. 11/6: G protein coupled systems
20. 11/11: From channels to action potentials and cellular signaling
[Preparation of grant proposals, due November 25]
12/2: Oral presentations of grant proposal
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