Chromatin Structure and Function (BIMS 824)
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Course director: Jeffrey Smith Spring semester 3 credits graded Faculty lectures and class discussions This course is designed to provide students with a broad understanding of the role that chromatin structure plays in multiple chromosomal processes. Emphasis is placed on the integration of structural, biochemical, and genetic approaches to chromatin function. Through a combination of faculty lectures and class discussions of assigned papers, both historical and current topics will be covered. A short research proposal on any covered topic will be assigned that is turned in at the end of the semester. The schedule below may be rearranged, but the topics will remain the same. Syllabus |
| January 19 | Class intro | |
| January 24 |
Nucleosome and chromatin structure |
Mitch Smith |
| January 26 | Class discussion | |
| January 31 | Post-translational histone modifications |
Patrick Grant |
| February 2 | Class discussion | |
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| February 7 | Histone acetyltransferase complexes |
Patrick Grant |
| February 9 | Class discussion | |
| February 14 | Histone deacetylase complexes | David Wotton |
| February 16 | Class discussion | |
| February 21 | Histone methyltransferase complexes |
Patrick Grant |
| February 23 | Class discussion | |
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| February 28 | ATP-dependent chromatin remodeling | David Auble |
| March 2 | Class discussion | |
| March 7 |
Spring Break |
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March 9 |
Spring Break |
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March 14 |
Signaling to chromatin | Rosalie Uht |
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March 16 |
Class discussion |
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March 21 |
DNA repair and chromatin |
Rong Li |
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March 23 |
Class discussion | |
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March 28 |
Chromosome condensation | Todd Stukenberg |
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March 30 |
Class discussion | |
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April 4 |
Kinetochores | Todd Stukenberg |
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April 6 |
Class discussion | |
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April 11 |
Heterochromatin and gene silencing | Jeff Smith |
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April 13 |
Class discussion | |
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April 18 |
X-chromosome inactivation | Jeff Smith |
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April 20 |
Class discussion | |
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April 25 |
Chromatin boundaries and insulators | Jeff Smith |
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April 27 |
Class discussion | |
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