Mucosal Immunology and Gut Inflammation
Given its close proximity to the intestinal contents, it is not surpising that the gastrointestinal tract has developed a unique immunological system. The system that has evolved does not respond to the presence of beneficial microbes, yet retains the ability to react quickly to the presence of harmful organisms.
The challenge faced by the mucosal immune system is to generate an immune reponse of appropriate magnitude to control the microbial invasion while maintaining the integrity of the epithelial barrier. An imbalanced or improper immune response can result in a variety of inflammatory disorders of the gut. Researchers in the DHCoE are seeking the causes and cures for a variety of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis.FacultyFabio Cominelli, M.D., Ph.D.
Theresa Pizarro, Ph.D.
Steven Cohn, M.D., Ph.D.