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Research Interests: The current focus of my laboratory is the dissection of the cell adhesion and migration pathways (chemokines and adhesion molecules) that initiate and maintain chronic intestinal inflammation, using novel mouse models of Crohn’s disease (CD) (SAMP-1/YitFc and TNFDARE mice). Our ultimate goals are 1. to identify potential new molecular targets for the treatment of CD, as well as 2. to identify adhesion molecules that may serve as markers of disease activity in inflammatory bowel disease.
Selected Publications: Rivera-Nieves J, Alfert J. 2000. Image of the Month. Gastroenterology 118(1): 3, 243 Rivera-Nieves J, Iezzoni J, Parrish C and Berg C. 2000. Persistent Transaminase Elevation in Anorexia Nervosa. Dig Dis Sci 45(10): 1959-1963. Kosiewicz MM, Nast C, Krishnan A, Rivera-Nieves J, Moskaluk CA, Matsumoto S, Kozaiwa K and Cominelli F. 2000. Th1-Type Responses Mediate Spontaneous Ileitis in a Novel Murine Model of Crohn’s Disease. Journal of Clinical Investigation 107(6): 695-702. Burns RC, Rivera-Nieves J, Moskaluk CA, Matsumoto S, Cominelli F and Ley KF. 2001. Antibody Blockade of ICAM-1 and VCAM-1 Ameliorates Inflammation in the SAMP-1/Yit Adoptive Transfer Model of Crohn’s Disease. Gastroenterology 121:1428-1436. Rivera-Nieves J, Bamias G, Alfert J, Bickston SJ, Moskaluk CA and Cominelli F. 2002. Intestinal Ischemia and Peripheral Gangrene in a Patient with Chronic Renal Failure. Gastroenterology 122: 495-499. Bamias G, Marini M, Ross WG, Weber B, Moskaluk CA, Rivera-Nieves J and Cominelli F. 2002. Down-regulation of Intestinal Lymphocyte Activation and Th1 Cytokine Production by Antibiotic Therapy in a Murine Model of Crohn’s Disease J Immunol 169:5308-5314. Rivera-Nieves J, Bamias G, Vidrich A, Marini M, Pizarro TT, McDuffie MJ, Cohn SM, Moskaluk CA and Cominelli F 2003. Emergence of Perianal Fistulizing Disease in the SAMP1/YitFc Mouse, a Spontaneous Model of Chronic Ileitis. Gastroenterology 124: 972-982. Marini M, Bamias G, Rivera-Nieves J, Moskaluk CA, Hoang SB, Ross WG, Pizarro TT and Cominelli F. 2003. TNF-alpha neutralization ameliorates the severity of murine Crohn’s-like ileitis by abrogation of intestinal epithelial cell apoptosis. PNAS in press. Abstracts:Rivera-Nieves J, McDonald LJ and Moss J. 1995. Peroxynitrite, a Reactive Oxygen Species Formed from Nitric Oxide and Superoxide, Inactivates GAPDH and Promotes its Modification by NAD. Am J Resp and Crit Care Med 151(4): A 187. Rivera-Nieves J and Moss J. 1997. Posttranslational Modifications of Proteins by Nitric Oxide. Am. J. Resp. and Crit. Care Med 155(4): A 758. Lee JH, Rivera-Nieves J, Rouhani F. and Brantly M. 1997. Structure Based Mechanism for the Formation of Inactive a-1-antitrypsin Following Large Scale Purification.. Am. J. Resp. and Crit. Care Med 155(4): A 652. Rivera-Nieves J and Moss J. 1998. Thiols Stimulate the Nitric Oxide-Independent Linkage of NADH to Glyceraldehyde-3-phosphate Dehydrogenase. The FASEB Journal 12(8): A1481. Rivera-Nieves J, Pizarro TT, Moskaluk CA and Cominelli F. 2000. TNF and IL12 are Key Mediators of Ileitis in Experimental Crohn’s Disease Gastroenterology 118(4) Suppl 2 A873.6 Rivera-Nieves J, Burns RC, Moskaluk CA, Pizarro TT, Ley K and Cominell F. 2000. Serum Levels of Soluble Intercellular Adhesion Molecule-1 (sICAM) Correlate with Severity of Ileitis in Experimental Crohn’s disease: A Novel Marker of Small Intestinal Inflammation. Gastroenterology 118(4) Suppl 2 A796. Burns RC, Rivera-Nieves J, Moskaluk CA, Kosiewicz MM, Cominelli F and Ley K. 2000. Adhesion Molecule Blockade Ameliorates Active Inflammation in Experimental Crohn’s Disease. Gastroenterology 118(4) Suppl 2 A341. Sayed B, Rivera-Nieves J, Coruh B, Makipour K, Kontoyannis D, Kollias G, Cominelli F and Pizarro TT. 2000. Further Characterization of TNF-induced CD-like ileitis in TNF DARE mice. Gastroenterology 118(4) A114. Rivera-Nieves, Pizarro TT, Kollias G, Moskaluk CA, Ley K and Cominelli F. 2001. Adhesion Molecule Expression and blockade in the TNF DARE Model of Crohn’s disease. 2001. Gastroenterology 120 (5) suppl.1 A 3707. Rivera-Nieves J. Bamias G, Weber B, Mounts J, Bickston SJ, Ley K and Cominelli F. 2001. Soluble P-selectin a sensitive marker of intestinal inflammation in Crohn’s disease. Gastroenterology 120 (5) suppl.1 A1430. Marini M, Rivera-Nieves J, Bamias G, Matsumoto S, Moskaluk CA, Pizarro TT, and Cominelli F. 2001. Anti-TNF Treatment decreases apoptosis of gut epithelial cells: a novel mechanism of anti-TNF therapy in experimental Crohn’s disease. Gastroenterology 120 (5) suppl.1 A1620. Odashima M, Linden J, Nast C, Moskaluk CA, Kozaiwa K, Sugawara K, Rivera-Nieves J, Matsumoto S and Cominelli F 2001. Antiinflammatory Effects of selective A2A receptor agonists in two animal models of Inflammatory Bowel Disease Gastroenterology 120 (5) suppl.1 A1448. Rivera-Nieves J, Bamias G, Olson T, Pizarro TT, Moskaluk CA, Ley, K and Cominelli F. 2002. Serum Levels of Soluble E-selectin (s E-sel) Correlate with Severity of Ileitis and systemic TNF levels in Experimental Crohn’s Disease. Gastroenterology 122 (4) suppl.1:T960, 2002. Rivera-Nieves J, Burns RC, Bachmann C, Olson T, Pizarro TT, Cominelli F and Ley K. 2002. Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1)-Blockade Ameliorates Inflammation in Experimental Crohn’s Disease. Gastroenterology 122 (4) suppl.1:T969, 2002. Rivera-Nieves J, Bamias G, Pizarro TT, McDuffie MJ, Ley K, Cohn S, Moskaluk CA and Cominelli F. 2002. Further Characterization of the SAMP1/YitFc Mouse Model of Experimental Crohn’s Disease (CD): A New Murine Model of Chronic Ileitis and Perianal Fistulizing Disease. Gastroenterology 122 (4) suppl.1: T955, 2002. Bamias G, Marini M, Ross WG, Weber B, Moskaluk CA, Rivera-Nieves J and Cominelli F.2002. Broad-spectrum antibiotic therapy ameliorates experimental ileitis by suppressing intestinal T cell activation and Th1 cytokine production. Gastroenterology 122 (4) suppl.1: M1056, 2002. Bamias G, Marini M, Ross WG, Moskaluk CA, Rivera-Nieves J and Cominelli F. 2002. IFNγ-producing lymphocytes mediate ileitis in the SAMP1/YitFc murine model of Crohn’s disease (CD) Gastroenterology 122 (4) suppl.1: 309, 2002.
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