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Research Interests:
Dr. Northup's research interests include liver tranplantation, portal hypertension, and hepatocellular carcinoma (HCC). With training in epidemiology, statistics, and outcome modeling, he is interested in liver transplantation outcomes and organ allocation policy. He is also currently studying the medical complications in long-term liver transplant survivors, including colon polyps and cancer and recurrent liver cirrhosis with hepatitis C. Dr. Northup has recently started studies in non-alcoholic liver disease associated with obesity and its changes after gastric bypass surgery. He is active in hepatocellular carcinoma, has developed (with Dr. Caldwell) a multidisciplinary clinic dedicated to the treatment of HCC and is working on studies evaluating new therapies for spontaneous bacterial peritonititis, hepatitis C, and upper GI bleeding.
Selected Publications:
McChesney JA, Northup PG , Bickston SJ. Acute acalculous cholecystitis associated with systemic sepsis and visceral arterial hypoperfusion - a case series and review of pathophysiology. Dig Dis Sci; 48(10): 1960-1967 Oct 2003.
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Northup PG, Berg CL. Pre-operative delta-MELD score does not independently predict mortality after liver transplantation. Am J Transplant; 2004 Oct; 4(10): 1643-9.
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Northup PG, Arseneau KO, Berg CL. Cost Minimization in Endoscopy Center Scheduling: A Controlled Trial. J Clin Gastroenterol; 2005 Apr 39(4): 268-272.
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Northup PG, Berg CL. Living Donor Liver Transplantation: The Historical and Cultural Basis of Policy Decisions and Ongoing Ethical Questions; Health Policy; 2005 May; 72 (2): 175-185.
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Northup PG, Wanamaker RC, Lee VD, Adams RB, Berg CL. Model for End-Stage Liver Disease (MELD) Predicts Nontransplant Surgical Mortality in Patients With Cirrhosis.Annals of Surgery. 242(2): 244-251, August 2005.
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Caldwell SH, Northup PG, Sundaram V. Correcting the coagulopathy of severe liver disease. In: Arroyo V and Rodes J, eds. Therapy of Liver Disease. Barcelona : ARS Medica, 2005
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Northup PG, Caldwell SH. Treatment of bleeding gastric varices [In Press]. Journal of Gastroenterology and Hepatology.
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Caldwell SH, Northup PG, Sundaram V. Haemostasis in liver disease [In Press]. In: Benhamou JP, Rizzetto M, Reichen J, Blei A, Rodes J, eds. Textbook in Hepatology. 3rd ed. Blackwell Publishing.
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Caldwell SH, Northup PG. Endoscopic management of gastric varices, GAVE, and portal gastropathy. In: Role of Endoscopy in Management of Patients with Liver Disease: Present Status and Future Prospects. American Society of Gastrointestinal Endoscopy, 56th annual post-graduate course, 2005 [In Press].
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