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Zhifeng  Shao
Degree(s): Ph.D.
Graduate School: University of Chicago
Primary Appointment: Professor of Molecular Physiology and Biological Physics
Research Interests:
Molecular Imaging and Single Molecule Biophysics

Email Address: zs9q@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Structural, Computational Biology and Biophysics
  • Biochemistry, Molecular Biology and Genetics
    • Research Description

    Our research covers several related but different areas. One of the major areas of research is the development of state of art instrumentation for biological studies. These have included the cryo atomic force micrscopy, video fluorescence microscopy, near field scanning ion and optical microscopy, single molecule manipulation and electron energy loss spectroscopy. Our recent scientific inquiries have included membrane assembled baterial toxin complexes, molecular motors (functional and structural), structure of chromatin, lamin B recceptor, analysis of model channels and nuclear structure.

    Selected Publications
  • Sheng, S., Czajkowsky, D.M. and Shao, Z. Localization of Linker Histone in Chromatosome by Cryo Atomic Force Microscopy. Biophysical Journal 91, L35-L37 (2006).
  • Czajkowsky, D.M., Iwamoto, H., Szabo, G., Cover, T.L. and Shao, Z. Mimicry of a Host Anion Channel by a Helicobacter pylori Pore-Forming Toxin. Biophysical Journal 89: 3093-3101 (2005).
  • Czajkowsky, D.M., Hotze, E.M., Shao, Z. and Tweten, R.K. Vertical Collapse of a Cytolysin Prepore Moves Its Transmembrane b-Hairpins To The Membrane. EMBO Journal 23: 3206-3215 (2004).
  • Sheng, S., Gao, Y., Somlyo, A.V., Somlyo, A.P. and Shao, Z. Cryo Atomic Force Microscopy of Unphosphorylated And Thiophosphorylated Single Smooth Muscle Myosin Molecules. Journal of Biological Chemistry 278: 39892-39896 (2003).
  • PubMed Listings for this Faculty Member
    • Intranet Profile
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    Contact Information
      Office Address: PO Box 800736, Jordan Hall, 480, 
      Office Phone: +1 434-982-0829, +1 434-924-1231
      Fax Phone: +1 434-982-1616

    Other Websites for this mentor:
    http://www.people.virginia.edu/%7Ezs9q/

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