University of Virginia Health System

 Lucy F. Pemberton
Associate Professor of Microbiology

Representative publications:

Del Rosario B.C and Pemberton, L.F. (2008) Nap1 links transcription elongation, chromatin assembly and mRNP biogenesis. Mol. Cell. Biol. 28: 2113-2124.

Calvert M, Keck K, Ptak C, Shabanowitz J, Hunt D and Pemberton, L.F. (2008). Phosphorylation by CK2 regulates Nap1 localization and function. Mol. Cell. Biol. 28: 1313-1325. 

Blackwell Jr, J.S., Wilkinson, S.T., Mosammaparast, N. and Pemberton, L.F. (2007) Mutational Analysis of H3 and H4 Amino Termini Reveals Distinct Roles in Nuclear Import.  J. Biol. Chem. 282, 20142-50.

Pemberton, L.F. and Paschal, B.P. Scientists Share Nuclear Secrets at Jekyll Island (2006) Traffic. 7, 751-760.

Hodges, J.L., Leslie, J.H., Mosammaparast, N., Guo, Y., Shabanowitz, J., Hunt, D.F., and Pemberton, L.F. (2005). Nuclear import of TFIIB is mediated by Kap114p, a karyopherin with multiple cargo binding domains. MBC. 16, 3200-3210.

Mosammaparast, N. Del Rosario, B. D, and Pemberton, L.F. (2005) Modulation of Histone Deposition by the Karyopherin Kap114. Mol Cell Biol. 25, 1764-1778.

Pemberton, L.F. and Paschal, B.P. Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export. (2005) Traffic. 6, 187-198.

Loch CM, Mosammaparast N, Miyake T, Pemberton LF, Li R. (2004) Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery. Traffic 5 :925-35

Mosammaparast N, and Pemberton LF. (2004) Karyopherins: from nuclear-transport mediators to nuclear-function regulators. Trends Cell Biol. 14:547-56.

Mosammaparast, N, Ewart, C. S., and Pemberton, L. F. (2002) A role for nucleosome assembly protein 1 in the nuclear transport of histones H2A and H2B. EMBO Journal. 21, 6527-6538.

   
Mosammaparast, N, Guo, Y., Shabanowitz, J., Hunt, D.F. and Pemberton, L.F. (2002) Pathways mediating the nuclear import of histone H3 and H4 in yeast. J. Biol Chem. 277, 862-868.

 
Mosammaparast, N., Jackson, K.R., Guo, Y., Brame, C.J., Shabanowitz, J., Hunt, D.F., and Pemberton, L.F. (2001) Nuclear import of histone H2A and H2B is mediated by a network of karyopherins. J. Cell Biol. 153, 251-262.

   
Pemberton, L. F., Rosenblum, J.S. and Blobel, G. (1999) Nuclear import of the TATA binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting. J. Cell Biol. 145, 1407-1417.

   
Albertini, M., Pemberton, L.F., Rosenblum, J.S. and Blobel, G. (1998) A novel nuclear import pathway for the transcription factor TFIIS. J. Cell Biol. 143, 1447-1455.

   
Rosenblum, J.S., Pemberton, L.F., Bonifaci, N. and Blobel, G. (1998) Nuclear import and the evolution of a multifunctional RNA-binding protein. J. Cell Biol. 143, 887-899.

   
Pemberton, L.F., Blobel, G. and Rosenblum, J.S. (1998) Transport routes through the nuclear pore complex. Curr. Opin. Cell Biol. 10, 392-399.

   
Pemberton, L.F., Rosenblum, J.S. and Blobel, G. (1997) A distinct and parallel pathway for the nuclear import of an mRNA-binding protein. J. Cell Biol. 139, 1645-1653.