David Wotton, Ph.D.
Assistant Professor of Biochemistry
and Molecular Genetics


Relevant Publications:

Kagey, M.H., Melhuish, T.A., and Wotton, D. (2003). The polycomb protein Pc2 is a SUMO E3. Cell. 113, 127-137.

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Melhuish, T.A., Gallo, C.M. and Wotton, D. (2001). TGIF2 interacts with histone deacetylase 1 and represses transcription. J. Biol. Chem. 276, 32109-14.

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Wotton, D., Knoepfler, P.S., Laherty, C.D., Eisenman, R.N. and Massagué, J. (2001). The Smad transcriptional corepressor TGIF recruits mSin3. Cell Growth and Differ. 12, 457-463.

Lo, R.S., Wotton, D. and Massagué, J. (2001). Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J. 20, 128-136.

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Wotton, D. and Massagué, J. (2001). Smad transcriptional corepressors in TGF family signaling. Current Topics in Microbiology and Immunology. 254, 145-164.

Melhuish, T.A. and Wotton, D. (2000). The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J. Biol. Chem. 275, 39762-6 .
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Gripp, K.W., Wotton, D., Edwards, M.C., Roessler, E., Ades, L., Meineke, P., Richieri-Costa, A., Zackai, E.H., Massagué, J., Muenke, M. and Elledge, S.J. (2000). Mutations in TGIF cause holoprosencephaly and link Nodal signaling to human neural axis determination. Nature Genetics. 25, 205-208.

Massagué, J. and Wotton, D. (2000). Transcriptional control by the TGFb/Smad signaling system.
EMBO J. 19, 1745-1754.
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Wotton, D., Lo, R.S., Swaby, L.A.C. and Massagué, J. (1999). Multiple modes of repression by the Smad transcriptional corepressor TGIF. J. Biol. Chem. 274, 37105-37110.
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Wotton, D., Lo, R.S., Lee, S. and Massagué, J. (1999). A Smad transcriptional corepressor. Cell. 97, 29-39.

Chen, Y.G., Hata, A., Lo, R.S., Wotton, D., Shi, Y., Pavletich, N., Massagué, J. (1998). Determinants of specificity in TGF-beta signal transduction. Genes & Dev. 12, 2144-2152.

Hata, A., Lo, R.S., Wotton, D., Lagna, G. and Massagué J. (1997). Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature. 388, 82-87.
 

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