University of Virginia Health System

Li, M. Stukenberg, P. T. and Brautigan, D. L. (2008) "Binding of Phosphatase Inhibitor-2 to  Prolyl Isomerase Pin1 Modifies Specificity for Mitotic Phosphoproteins" Biochemistry 47: 292-300  PMID 18062707

Stefansson, B., Ohama, T., Daugherty, A.E. and Brautigan, D.L. (2008) Protein Phosphatase PP6 Subunits Composed of Ankyrin Repeats. Biochemistry, 47, 1442-1451 PMID 18186651

Fuller, B. G., Lampson, M. A., Foley, E. A., Rosasco-Nitcher, S., Le, K. V., Tobelman, P., Brautigan, D.L., Stukenberg, P.T., and Kapoor, T.M. (2008) "Midzone Activation of Aurora B in Anaphase Produces an Intracellular Phosphorylation Gradient" Nature 453: 1132-1136. PMID 18463638

Molhoek, K. R., Griesemann, H.,  Shu, J., Gershenwald, J. E., Brautigan, D. L. and C. L. Slingluff, Jr. (2008) "Human melanoma cytolysis by combined inhibition of VEGF/VEGFR-2 autocrine growth loop and of mTOR." Cancer Res. 86: 4392-4397. PMID 18519701

Yoo, S. J., Jimenez, R.H., Sanders, J. A., Boylan, J. M., Brautigan, D. L. and Gruppuso, P. A. (2008) "The 4-Containing Form of Protein Phosphatase 2A in Liver and Hepatic Cells" J. Cell. Biochem. (in press)

Prickett, T.D., Ninomiya-Tsuji, J., Muratore, T. L., Shabanowitz, J., Hunt, D.F.  and Brautigan, D. L. (2008) "Activation of TAK1-TAB1 Phosphorylation and Signaling to NF-B by TAB4." J. Biol. Chem 283: 19245-19254. PMID 18456659 published on-line May 2, 2008

Wang, W., Chronmiller, C., and Brautigan, D. L.  (2008) "Phosphatase inhibitor-2 is a maternal gene required for mitotic synchrony in Drosophila embryogenesis" Genetics (in press)

Smith, S.C. Oxford, G., Baras, A.S., Owens, C., Havaleshko, D., Brautigan, D.L., Safo, M.K., Theodorescu, D. (2007) "Expression of Ral GTPases, Their Effectors, and Activators in Human Bladder Cancer" Clin. Cancer Res. 13: 3803-3813  PMID  17606711

Eto, M., Kitazawa. T., Matsuzawa, F., Aikawa, S., Kirkbride, J. A., Isozumi, N., Nishimura, Y., Brautigan, D. L., and Ohki, S. (2007) Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. Structure, 15: 1591-1602.  PMID  18073109

Guo, C. Mi, J., Brautigan, D.L. and Larner, J.M. (2007) "ATM Regulates Ionizing Radiation-induced Disruption of HDAC1:PP1:Rb Complexes" Cellular Signalling 19 (3): 504-510

Mi, J., Guo, C. Brautigan, D. L. and Larner, J. M. (2007)  "Protein phosphatase-1 alpha Regulates Centrosome Separation and Duplication through Nek2A"  Cancer Res. 67: 1082-1089.    PMID 17283141

Li, M., Satinover, D.L. and  D. L. Brautigan (2007) "Phosphorylation and Functions of Family of Inhibitor-2" Biochemistry (ACS) 46: 2380-2389 PMID 17286390

Yoo, S. J.-S., Boylan, J. M., Brautigan, D. L. and P. A. Gruppuso  (2007) Subunit Composition and Developmental Regulation of Hepatic Protein Phosphatase 2A (PP2A) Arch. Biochem. Biophys. 461:186-193 doi:10.1016/j.abb.2007.02.019

Yang, C-S., Xin, H-W., Kelley, J. B., Spencer, A., Brautigan, D.L., and Paschal, B. M. (2007) "Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions." Mol. Cell. Biol. 27: 3390-3404.

Eto, M., Kirkbride, J., Elliott, E., Lo, S.H., and Brautigan, D. L. (2007) Association of the tensin PTP domain with alpha isoform of protein phosphatase-1 in focal adhesions."  J. Biol. Chem 282: 17806-17815 on-line 15 April, PMID 17435217

Prickett, T.D. and D. L. Brautigan (2007) " Cytokine activation of p38MAPK and apoptosis is opposed by alpha-4 targeting of PP2A for site-specific dephosphorylation of MEK3"  Mol. Cell. Biol. 27:  4217-4227  (on-line 16 April, PMID 17438131)

Stefansson, B., and Brautigan, D.L. (2007) Protein Phosphatase PP6 N terminal Domain Restricts G1 to S Phase Progression in Human Cancer Cells. Cell Cycle  6: 1386-1392 PMID 17568194

Swain, J. E., Ding, J., Brautigan, D. L., Villa-Moruzzi, E., and Smith, G.D. (2006) "Chromatin Condensation and Maintenance of Histone-H3 Phosphorylation During Mouse Oocyte Meiosis Requires Regulation of Protein Phosphatase Activity" Biol. Reprod. (in press)

Satinover, D. L., Brautigan, D.L. and Stukenberg, P.T. (2006) "Aurora A kinase and Inhibitor-2 regulate the Cyclin Threshold for Mitotic Entry in Xenopus Early Embryonic Cell Cycles." Cell Cycle (in press)

Brautigan, D. L.  (2006) "Protein phosphatase inhibitor-2" Protein A001939, peer-reviewed molecule page for Alliance for Cell Signaling/Nature Publ. Group published on line 20 January 2006 doi:10.1038/mp.a001939.01

Eto, M. and Brautigan, D. L. (2006) "CPI-17" Myosin Phosphatase inhibitor protein, Protein A002849 peer-reviewed molecule page for Alliance for Cell Signaling/Nature Publ. Group published on line 20 January 2006  doi:10.1038/mpa002849.01

Brautigan, D. L. and Eto, M.  (2006) "PNG" (Ppp1r14b) PP1 Inhibitor Protein, Protein A002884 peer-reviewed molecule page for Alliance for Cell Signaling/Nature Publ. Group      published on line 11 April 2006  doi:10.1038/mpa002884.01

Gianchandani, E. P. Brautigan, D. L. and Papin, J. A. (2006) "Systems analyses characterize integrated functions of biochemical networks" Trends in Biochem. Sci. 31: 284-291.  doi:10.1016/j.tibs.2006.03.007  online 17 April 2006

Stefansson, B. and Brautigan, D. L. (2006) "Protein Phosphatase 6 Subunits with Conserved SAPS Domain Target I?B?" J. Biol. Chem. 281: 22624-22634. published on-line June 12, 2006 doi:10.1074/jbc.M601772200

Brautigan, D. L., Kruszewski, A., Wang, H. (2006) "Chromium and Vanadate Combination Increases Insulin-Induced Glucose Uptake in 3T3-L1 Adipocytes"  Biochem. Biophys. Res. Commun. 347: 769-773. doi:10.1016/j.bbrc.2006.06.154

Wang, H. and D. L. Brautigan (2006) Peptide Microarray Analysis of Substrate Specificity of the Transmembrane Ser/Thr Kinase KPI-2 Reveals Reactivity with CFTR and Phosphorylase. Molec. Cell. Proteomics, published on-line August 3, 2006, doi: 10.1074/mcp.M600188-MCP200

Prickett, T. D. and D. L. Brautigan (2006) "The Alpha-4 Regulatory Subunit Exerts Opposing Allosteric Effects on Protein Phosphatases PP6 and  PP2A." J. Biol. Chem. published on-line August 8, 2006 doi:10.1074/jbc.M601054200