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Wladek  Minor
Degree(s): Ph.D.
Graduate School: University of Warsaw
Primary Appointment: Professor of Molecular Physiology and Biological Physics
Research Interests:
Structure-Function Relationships in Proteins; Structural Genomics; Bioinformatics

Email Address: wm4n@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Structural, Computational Biology and Biophysics
  • Biomedical Engineering
    • Research Description

    Our laboratory studies macromolecular structure with an aim toward in-depth understanding of structure-function relationships. X-ray diffraction analysis is our primary research tool, but we also employ other physical and biochemical methods of analysis. The program emphasizes two broad themes: crystallographic studies on molecules of immediate interest, and methodology development. Most of the macromolecules that we have under study relate to one or more of a few broad biological areas: cellular signal transduction and metalloproteins. The same systems have been chosen as subjects for methodology development. The methodology development includes the development of various crystallographic tools that create the HKL package. Another research area is high-throughout crystallography and structural genomics. Our lab is a member of Midwestern Center for Structural Genomics Consortium. We develop high-throughput crystallography equipment - integrated system for data collection and analysis has been installed at X9B beamline at NSLS.

    Selected Publications
  • Zimmerman MD, Proudfoot M, Yakunin A, Minor W (2008) Structural Insight into the Mechanism of Substrate Specificity and Catalytic Activity of an HD-Domain Phosphohydrolase: The 5'-Deoxyribonucleotidase YfbR from Escherichia coli Journal of Molecular Biology 378: 215-26. Times cited: 1. [Pub Med ID: 18353368]
  • Otwinowski Z, Minor W (1997) Processing of X-ray diffraction data collected in oscillation mode Methods in Enzymology 275: 307-326. Times cited: 18516.
  • Minor W, Steczko J, Stec B, Otwinowski Z, Bolin JT, Walter R, Axelrod B (1996) Crystal structure of soybean lipoxygenase L-l at 1.4 angstrom resolution Biochemistry 35: 10687-701. Times cited: 219. [Pub Med ID: 8718858]
  • Minor W, Steczko J, Bolin JT, Otwinowski Z, Axelrod B (1993) Crystallographic Determination Of The Active-Site Iron And Its Ligands In Soybean Lipoxygenase L-1 Biochemistry 32: 6320-3. Times cited: 116. [Pub Med ID: 8518276]
  • Link to Dr. Minor's Publication Page
    • Intranet Profile
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    Contact Information
      Office Address: PO Box 800736, Jordan Hall, 4223, 
      Office Phone: +1 434-243-6865
      Fax Phone: +1 434-982-1616
      Web Site: http://krzys.med.virginia.edu/CrystUVa

    Other Websites for this mentor:
    http://krzys.med.virginia.edu/CrystUVa/wladek.htm

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