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Helmy  M.  Siragy
Degree(s): M.D.
Graduate School: Tanta Univ, Egypt
Primary Appointment: Professor of Medicine, Endocrinology and Metabolism
Research Interests:
Biology and Pathophysiology of Angiotensin Receptor Subtypes in the Kidney and Heart Diseases

Email Address: hms7a@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Biochemistry, Molecular Biology and Genetics
  • Biomedical Engineering
    • Research Description

    Dr. Helmy M. Siragy developed the microdialysis technique, which led to a golden Age of revolutionary discoveries about the nature of angiotensin receptors and renal paracrine hormones. The lab focuses on the biology and pathophysiology of angiotensin subtype receptors in cardiovascular system. Currently the lab is conducting pioneering translational research that has major clinical impact and is related to cardiac ischemia, diabetic kidney disease, local tissue production of aldosterone and its paracrine functions in kidney and heart. Our Lab is also involved in clinical studies related to aldosterone pulse activity in normal individuals and in patients with primary aldosteronism, vasopressin receptors in kidney and management of hyponatremia, and one of our ongoing studies investigating the effects of long term angiotensin subtype 1 receptor blockade on cardiovascular morbidity and mortality.

    Selected Publications
  • Siragy HM, Xue C, Abadir P, Carey RM. Angiotensin subtype-2 receptors inhibit renin biosynthesis and angiotensin II formation. Hypertension. 2005 Jan;45(1):133-7.
  • Siragy HM. Clinical trials report. VALIANT: another milestone for angiotensin receptor blockers. Curr Hypertens Rep. 2004 Aug;6(4):255-6.
  • Gibbons GH, Liew CC, Goodarzi MO, Rotter JI, Hsueh WA, Siragy HM, Pratt R, Dzau VJ. Genetic markers: progress and potential for cardiovascular disease. Circulation. 2004 Jun 29;109(25 Suppl 1):IV47-58.
  • Siragy HM. AT1 and AT2 receptor in the kidney: role in health and disease. Semin Nephrol. 2004 Mar;24(2):93-100.
  • PubMed Listings for this Faculty Member
    • Intranet Profile
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    Contact Information
      Office Address: PO Box 801409, Fontaine Research Park 450 Ray C. Hunt Dr., 
      Office Phone: +1 434-924-2961
      Fax Phone: +1 434-982-3626

    Other Websites for this mentor:
    http://healthsystem.virginia.edu/internet/siragy/

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