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Robin  A.  Felder
Degree(s): Ph.D.
Graduate School: Georgetown University
Primary Appointment: Professor of Pathology
Research Interests:
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

Email Address: raf7k@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Molecular Medicine
  • Biomedical Engineering
    • Research Description

    During the course of our studies we employ in vitro and in vivo experiments. We have been using molecular genetics and biochemical techniques to examine adrenergic receptors and to determine their intracellular second messengers. Through the use of in vivo pharmacologic experiments we have examined the physiologic effects mediated through the adrenergic receptors and their end effectors. Ultimately, we use human subjects in the Clinical Research Center to determine the effect of pharmacologic intervention in normal and pathologic states. Our current efforts are directed towards the study of the relationship between the dopaminergic system and essential hypertension. Our applied research includes medical automation, robotics and artificial intelligence, managing the automated laboratory. The medical automation research center is a group of faculty from various engineering departments and the Health Sciences Center who are interested in bringing novel robot and computer technology to bear on medical problems. We have already implemented mobile robots, machine vision and other novel technologies in the clinical laboratory.

    Selected Publications
  • Zeng C, Yu P, Zheng S, Yang Z, Jones JE, Asico LD, Hopfer U, Eisner G, Felder RA, Jose PA. D3 dopamine receptor decreases AT1 angiotensin receptor expression in rat renal proximal tubular cells.
  • Bengra C, Mifflin TE, Khripin Y, Manunta P, Williams SM, Jose PA, Felder RA. Genotyping essential hypertension SNPs using a homogeneous PCR method with universal energy transfer primers. Clinical Chemistry.2002.
  • Felder RA, Sanada H, Xu J, Yu P-Y, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, Williams S, Gainer J, Brown NJ, Hazen-Martin D, Wong L-J, Robillard JE, Carey RM, Eisner GM, Jose PA. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci USA 99:3872-3877, 2002.
  • Lau YS, Hendley ED, Felder RA, Jose PA. Hyperactivity and elevated renal cortical calmodulin-dependent protein kinase activity. Clin Exp Hypertens 2002; 24:289-300.
  • PubMed Listings for this Faculty Member
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    Contact Information
      Office Address: PO Box 801400, Aurbach, 450 Ray C. Hunt Dr., Fontaine Res, 
      Office Phone: +1 434-981-0749
      Fax Phone: +1 434-924-5718
      Web Site: http://marc.med.virginia.edu

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