University of Virginia Health System

Gary  Balian,  Ph.D. Professor of Orthopaedic Surgery Targeted delivery to cells and tissues Eugene  J.  Barrett,  M.D., Ph.D. Professor of Medicine Diabetes and Insulin Action Paula  Q.  Barrett,  Ph.D. Professor of Pharmacology Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses. Douglas  A.  Bayliss,  Ph.D. Professor and Chair of Pharmacology Mechanisms of Neuromodulation in Central Neurons Timothy  P.  Bender,  Ph. D. Professor of Microbiology Regulation of gene expression during lymphocyte development James  P.  Bennett,  Jr.,  M.D., Ph.D. Professor of Neurology Neurodegenerative Diseases George  S.  Bloom,  Ph.D. Professor of Biology Cellular Morphogenesis and Motility; Cell Biology of Alzheimer's Disease Amy  H.  Bouton,  Ph.D. Professor of Microbiology Signaling Pathways that Regulate Tumor Growth, Metastasis, and Response to Anticancer Agents; Adhesion Signaling In Macrophages; Bacteria-Host Cell Interactions Thomas  J.  Braciale,  M.D., Ph.D. Professor of Pathology T Lymphocyte Responses To Virus Infection David  L.  Brautigan,  Ph.D. Professor of Microbiology Protein Ser/Thr Phosphatases in Cell Signaling and Cell Cycle Timothy  N.  Bullock,  Ph.D. Assistant Professor of Pathology Generation of vaccines to tumors John  H.  Bushweller,  Ph.D. Professor of Molecular Physiology and Biological Physics Structural and Functional Basis for Oncogenesis; Targeted Drug Development; Structural Studies of Membrane Proteins John  M.  Chirgwin,  Ph.D. Professor of Medicine Tumor-Secreted AMF: Causal Role in an Animal Model of Cachexia. Steven  M.  Cohn,  M.D., Ph.D. Associate Professor of Medicine Communication between the Immune System and Epithelium in Chronic Inflammatory Intestinal Diseases. Patrick  J.  Concannon,  Ph.D. Professor of Biochemistry and Molecular Genetics Cellular DNA damage responses; Breast cancer genetics; Genetics of type 1 diabetes Carl  E.  Creutz,  Ph.D. Professor of Pharmacology Calcium-dependent, Membrane-binding Proteins and Mechanisms of Exocytosis Janet  V.  Cross,  Ph.D. Assistant Professor of Pathology Molecular Mechanisms of Cancer Chemoprevention and Anti-Inflammatory Benefits of Dietary Nutrient Compounds Brian  R.  Duling,  Ph.D. Professor of Molecular Physiology and Biological Physics Cell-cell signaling in the Microvascular Wall Anindya  Dutta,  M.D., Ph.D. Professor of Biochemistry and Molecular Genetics DNA Replication and Genomic Instability in Cancer Cells Daniel  A.  Engel,  Ph.D. Associate Professor of Microbiology Transcriptional Regulation in Cancer Cells Victor  H.  Engelhard,  Ph.D. Professor of Microbiology Immune responses to tumors and immunotherapy / Impact of self-tolerance on anti-tumor immunity / Processing and presentation of MHC-restricted antigens Loren  D.  Erickson,  Ph.D. Assistant Professor of Microbiology Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus and multiple myeloma; Immunotherapeutics in the treatment of B cell disorders Robin  A.  Felder,  Ph.D. Professor of Pathology Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers. Daniel  R.  Foltz,  Ph.D. Assistant Professor of Biochemistry and Molecular Genetics Assembly and Function of Centromeric Chromatin Jay  W.  Fox,  Ph.D. Professor and Assistant Dean of Research Support of Microbiology Basement Membrane Structure and Metalloproteinases Brent  A.  French,  Ph.D. Associate Professor of Biomedical Engineering Novel Therapies for Treating and Preventing Ischemic Heart Disease Shu-Man  Fu,  M.D., Ph.D. Professor and Division Chief of Medicine Human Lymphocyte Biology and Autoimmunity James  C.  Garrison,  II,  Ph.D. Professor of Pharmacology Role of the G protein &alpha and &beta&gamma Subunits in Cell Signaling Benjamin  M.  Gaston,  M.D. Professor of Pediatrics Allergy and Respiratory Medicine Adrian  R.L.  Gear,  D.Phil. Professor of Biochemistry and Molecular Genetics Blood-platelet function; Cardiovascular disease; Inflammation Lisa  Goehler,  Ph.D. Assistant Professor of Psychology Psychoneuroimmunology; immunosensation; organizational features of autonomic sensory systems Joanna  B.  Goldberg,  Ph.D. Professor of Microbiology Mechanisms of Bacterial Pathogenesis Adam  N.  Goldfarb,  M.D. Associate Professor of Pathology Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis Richard  L.  Guerrant,  M.D. Professor of Medicine Recognition, Diagnosis, Pathogenesis, Impact, Treatment and Prevention of Enteric Infections; Global Health and Tropical Infectious Diseases Theresa  Guise,  M.D. Professor of Medicine Barry  M.  Gumbiner,  Ph.D. Professor and Chair of Cell Biology Cell Adhesion and Morphogenesis; Wnt Signaling; Cadherins and Catenins; Development and Cancer Patrice  G.  Guyenet,  Ph.D. Professor of Pharmacology Neural Control of Blood Pressure and Respiration Young  S.  Hahn,  Ph.D. Associate Professor of Microbiology Immune Suppression by Hepatitis C Virus Joyce  L.  Hamlin,  Ph.D. Professor and Chair of Biochemistry and Molecular Genetics Control of Mammalian Chromosomal DNA Replication, and DNA Damage, Repair and Genetic Instability in Cancer Marie-Louise  Hammarskjold,  M.D., Ph.D. Professor of Microbiology Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses Kevin  C.  Hazen,  Ph.D. Professor of Pathology Fungal pathogenesis. Fungal surface proteins and hydrophobicity. Catherine  C. "Lynn"  Hedrick,  Ph.D. Associate Professor of Medicine Atherogenesis; hyperglycemia and insulin resistance John  C.  Herr,  Ph.D. Professor of Cell Biology Differential Gene Expression During Spermiogenesis and Oogenesis in Application to Contraceptive Drug and Vaccine Development Erik  L.  Hewlett,  M.D. Professor of Medicine Structure and Function of Bacterial Toxins: Roles in Microbial Pathogenesis and Uses in Biomedical Research Barry  T.  Hinton,  Ph.D. Professor of Cell Biology Cell And Molecular Biology of Epididymal Function Joel  W.  Hockensmith,  Ph.D. Associate Professor of Biochemistry and Molecular Genetics Chemistry and Biology of Nucleic Acids; DNA-Dependent ATPase Mechanisms; DNA-Protein Interactions Isa  M.  Hussaini,  Ph.D. Associate Professor of Pathology The Roles of PKC-eta and LRP in Glioblastoma Invasive Growth Brant  Isakson,  Ph.D. Assistant Professor of Molecular Physiology and Biological Physics Intercellular communication in normal and disease state vasculature. Michael  L.  Johnson,  Ph.D. Professor of Pharmacology Mathematical modeling of biological processes Masashi  Kawasaki,  Ph.D Professor of Biology Neuroethology of electric fish Dean  H.  Kedes,  M.D., Ph.D. Associate Professor of Medicine Human Herpes virus Associated with Kaposi's Sarcoma Susanna  R.  Keller,  M.D. Assistant Professor of Medicine Insulin-regulated Membrane Trafficking and Modification of Cell Surface Function Andrei  Khokhlatchev,  Ph.D. Assistant Professor of Pathology Molecular Mechanisms of Tumor Suppression by NORE1A family of Proteins Sepideh  Khorasanizadeh,  Ph.D. Associate Professor of Biochemistry and Molecular Genetics Biophysical Characterization of Epigenetic Signaling Jonathan  Kipnis,  Ph.D. Assistant Professor of Neuroscience Neuro-Immune Interactions Howard  C.  Kutchai,  Ph.D. Professor and Acting Chair of Molecular Physiology and Biological Physics Quaternary Structure of Na, K-ATPase and Its Regulatory Significance Deborah  A.  Lannigan,  Ph.D. Associate Professor of Microbiology Kinases, Drugs and Breast Cancer Victor  E.  Laubach,  Ph.D. Associate Professor of Research of Surgery Mechanisms of Compensatory Lung Growth and Lung Ischemia-Reperfusion Injury Kevin  S.  Lee,  Ph.D. Professor and Chair of Neuroscience Neuronal Vulnerability: A Study of Cellular Mechanism Norbert  Leitinger,  Ph.D. Associate Professor of Pharmacology Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes. Chien  Li,  Ph.D. Assistant Professor of Pharmacology Neuroendocrine regulation of energy balance and stress, regulation of pancreatic islet hormone secretion and glucose homeostasis. Joel  M.  Linden,  Ph.D. Professor and Vice Chairman of Research of Medicine Adenosine Signaling in Inflammation and Diabetes Ulrike  M.  Lorenz,  Ph.D. Associate Professor of Microbiology Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways Kevin  R.  Lynch,  Ph.D. Professor of Pharmacology Molecular Pharmacology of Lysophospholipid Mediators Mani  S.  Mahadevan,  M.D. Associate Professor of Pathology Molecular Mechanisms of Myotonic Muscular Dystrophy James  W.  Mandell,  M.D., Ph.D. Associate Professor of Pathology Mechanisms of Brain Astroglial Activation in Neural Injury Barbara  J.  Mann,  Ph.D. Associate Professor of Medicine Pathogenicity of Francisella tularensis and the human parasite Entamoeba histolytica, vaccines Marty  W.  Mayo,  Ph.D. Associate Professor of Biochemistry and Molecular Genetics Transcriptional Regulation by NFKB Marcia  J.  McDuffie,  M.D. Professor of Microbiology Genetic analysis of autoimmunity Coleen  A.  McNamara,  M.D. Associate Professor of Medicine Role of Id3 and Id3a in Regulating the Smooth Muscle Cell Response to Vascular Injury Gene Delivery Suzanne  M.  Moenter,  Ph.D. Professor of Medicine Understanding How the Central Nervous System Controls Fertility through Study of Gonodotropin-realeasing Hormone Neurons Joseph  Randall  Moorman,  M.D. Professor of Medicine Mathematical Analysis of Cardiac Rhythms Christopher  A.  Moskaluk,  M.D., Ph.D. Associate Professor of Pathology Molecular pathogenesis and genomic analysis of human cancers David  W.  Mullins,  Ph.D. Assistant Professor of Microbiology Immunotherapy; Tumor Immunology Robert  K.  Nakamoto,  Ph.D. Professor of Molecular Physiology and Biological Physics Structure-Function of Active Transporters Roy  C.  Ogle,  Ph.D. Professor of Medicine Stem Cells, Growth Factor Receptors and Tissue Engineering Mark  D.  Okusa,  M.D. Professor of Medicine Mechanisms of renal injury Gary  K.  Owens,  Ph.D. Professor of Molecular Physiology and Biological Physics Molecular Control of Smooth Muscle Cell Differentiation Sarah (Sally)  J.  Parsons,  Ph.D. Professor of Microbiology Molecular mechanisms of Src family tyrosine kinases in mitogenesis, tumorigenesis, and neuronal activity. Lisa  M.  Pastore,  Ph.D. Assistant Professor of Research of Obstetrics & Gynecology Epidemiology Edward  Perez-Reyes,  Ph.D. Professor of Pharmacology Molecular Pharmacology of Voltage-gated Calcium Channels William  A.  Petri,  Jr.,  M.D., Ph.D. Professor and Division Chief of Medicine Molecular Mechanisms of Pathogenesis of Parasitic Infection Fraydoon  Rastinejad,  Ph.D. Associate Professor of Pharmacology Analysis of Nuclear Receptor Complexes with DNA and Ligands Kodi  S.  Ravichandran,  B.V.Sc., Ph.D. Professor of Microbiology Intracecellular signaling in lymphocytes and phagocytes Prabhakara  P.  Reddi,  Ph.D. Assistant Professor of Pathology Transcriptional Regulation of Mammalian Spermatogenesis David  M.  Rekosh,  Ph.D. Professor of Microbiology Human Immunodeficiency; Virus Gene Expression Christopher  M.  Rembold,  M.D. Professor of Medicine Smooth Muscle Signal Transduction Nitric Oxide Emilie  F.  Rissman,  Ph.D. Professor of Biochemistry and Molecular Genetics Mammalian Behavior Genetics Michele  Sale,  Ph.D. Associate Professor of Medicine Genetics of vascular disease; Genetics of otitis media Ira  G.  Schulman,  Ph.D. Associate Professor of Pharmacology Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism, atherosclerosis, Small molecule approaches to drug discovery. Zhifeng  Shao,  Ph.D. Professor of Molecular Physiology and Biological Physics Molecular Imaging and Single Molecule Biophysics Margaret  A.  Shupnik,  Ph.D. Professor of Medicine Hypothalamic peptide and steroid regulation of pituitary gene transcription; Estrogen action in neuroendocrine and reproductive tissues; Estrogen action in breast cancer Corinne  M.  Silva,  Ph.D. Associate Professor of Medicine STAT5b signaling in tyrosine kinase-dependent and anti-estrogen resistant breast cancers Avril  V.  Somlyo,  Ph.D. Professor of Molecular Physiology and Biological Physics Signaling pathways that regulate contractility in smooth muscle tissues and migrating cells in normal and disease states such an coronary artery disease, asthma and hypertension. Structure function studies of the intercalated disk in the heart. Ann  E.  Sutherland,  Ph.D. Associate Professor of Cell Biology Cell Matrix Interactions In Mouse Development Lukas  K.  Tamm,  Ph.D. Professor of Molecular Physiology and Biological Physics Biomembrane Structure and Function; Membrane Fusion in Viral Cell Entry and Exocytosis; Lipid-Protein Interactions Ronald  P.  Taylor,  Ph.D. Professor of Biochemistry and Molecular Genetics Clearance of Pathogens: The role of complement in Immunotherapy: New approaches to vaccine generation Dennis  J.  Templeton,  M.D., Ph.D. Professor and Chair of Pathology Cell Death in Cancer Progression; Stress-Mediated Signal Transduction; Cancer Chemoprevention; Stress Inhibitors in Inflammatory Diseases Dan  Theodorescu,  M.D., Ph.D. Professor of Urology Cell Signaling in Tumor Invasion and Metastasis, Metastasis Suppressor genes, Biomarkers, Translational Research in Prostate and Bladder Cancer. Slobodan  M.  Todorovic,  M.D., Ph.D. Associate Professor of Anesthesiology Pharmacology and function of T-type (low-voltage-activated, LVA) calcium channels in sensory transmission. Amy  L.  Tucker,  M.D. Associate Professor of Medicine General cardiology, adult congenital heart disease; Adenosine receptors Kenneth  S.  Tung,  M.D. Professor of Pathology Tolerance and Autoimmunity: My laboratory explores the fundamental mechanisms of prevention and induction of autoimmune diseases of clinical relevance. Jeremy  B.  Tuttle,  Ph.D. Professor of Neuroscience Neurodegenerative and Aging Dysfunction at the Cellular Level Scott  B.  Vande Pol,  M.D., Ph.D. Associate Professor of Pathology We study papillomavirus oncoproteins as probes to elucidate cellular pathways regulating cellular signal transduction, and the development of cancer. Projects: Oncoprotein E6 and the regulation of integrin signaling and Cdc48. Brian  R.  Wamhoff,  Ph.D. Assistant Professor of Medicine Atherosclerosis/Restenosis; Excitation Transcription Coupling; Biomedical Models of Vascular Disease. Gail  W.  Wertz,  Ph.D. Professor of Pathology Molecular Virology, Transcriptional Control, Viral Vaccine Development Michael  C.  Wiener,  Ph.D. Associate Professor of Molecular Physiology and Biological Physics Structural biology (esp. crystallography) of integral membrane proteins; TonB-dependent active transport across the bacterial outer membrane; cancer-related membrane proteins; crystallization methods development Mark  B.  Williams,  Ph.D. Associate Professor of Radiology Design, Development and Optimization of Medical Imaging Technologies W.  Michael  Wormington,  Ph.D. Associate Professor of Biology Post-Transcriptional Regulation of Gene Expression During Oogenesis and Early Development David  Wotton,  Ph.D. Associate Professor of Biochemistry and Molecular Genetics Regulation of Gene Expression and Development by Transcriptional Repressors J.  Julius  Zhu,  Ph.D. Assistant Professor of Pharmacology Mechanisms of Synaptic Plasticity and Mental Retardation