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Translational Research

Julie Sando, Ph.D., Professor of Research

ResearcherGeneral anesthetics have been used clinically for over 100 years but their mechanism of action is not yet defined. The Myer-Overton correlation of anesthetic potency with oil-water partitioning has suggested interaction with both membrane lipids and with hydrophobic domains of proteins.

[Julie Sando, Ph.D.]

Ganesan Kamatchi, Ph.D., Assistant Professor of Research

Researcher Efforts in the laboratory are directed towards determining how anesthetic agents interfere with the enzyme protein kinase C and calcium channels. We have identified the sites of action of protein kinase C on various members of the calcium channels by comparing their amino acid sequence and also the evidence based on the published literature.

[Ganesan Kamatchi, Ph.D.]

Slobodan Todorovic, M.D., Ph.D., Associate Professor of Anesthesiology

Researcher Our research interests involve studies of pharmacology and function of T-type (low-voltageactivated, LVA) calcium channels in sensory transmission. These channels have been identified in a variety of excitable and non-excitable cells.

[Slobodan Todorovic, M.D., Ph.D.]

Vesna Todorovic, M.D., Ph.D., Associate Professor of Anesthesiology

Researcher Broadly, my research interests focus on mechanisms by which anesthetic drugs interact with neurotransmitter systems in the central nervous system to produce both pharmacological and toxicological effects.

[Vesna Todorovic, M.D., Ph.D.]

Zhiyi Zuo, M.D., Ph.D., Associate Professor Anesthesiology & Neuroscience

Researcher The research focuses in my laboratory are two: the regulation of glutamate transporters and neuroprotection.

[Zhiyi Zuo, M.D., Ph.D.]

Manoj Patel, Ph.D., Assistant Professor of Research

My research interests are divided into two main areas:

Researcher
  1. Modulation of sodium channel gating by beta subunits and novel sodium channel blockers.
  2. The role of sodium channels in epilepsy.

[Manoj Patel, Ph.D.]

Lisa A. Palmer, Ph.D., Associate Professor of Research

Researcher Our laboratory examines the regulation of the transcription factor hypoxia inducible factor-1 (HIF-1) by nitric oxide. We are currently examining (1) the mechanism by which NO induces the expression of HIF-1 and (2) the role of NO induced HIF-1 in the development of pulmonary hypertension.

[Lisa A. Palmer, Ph.D.]