Events Calendar - School of Medicine

 

Type:
All
Department:
School of Medicine [x]
Audience:
All
CME:
All
  • Sunday
  • Monday
  • Tuesday
  • Wednesday
  • Thursday
  • Friday
  • Saturday
  • Date
  • Time
  • Event
  • Department

Thu21

09:30 AM

day:
Thursday
date:
11/21/2019
time:
9:30 AM - 10:30 AM
event:
"The Role of Mitochondrial ROS Production in Health and Disease"-2019 Joseph Larner Memorial Lecture in Pharmacology by Michael Murphy, PhD
location:
PHCC Auditorioum 1st floor Pinn Hall
type:
Lecture
department:
Pharmacology
audience:
Everyone Students
details:
A lectureship was established to honor the memory of Joseph Larner, who served as Professor and Chair of the Pharmacology Department for many years. During his time as Chair he recruited and mentored numerous successful faculty, including Al Gilman. He continued to be an inspiration to everyone who knew him, especially our graduate students, who were in awe of his energy and enthusiasm as he kept up his science and maintained an active departmental presence well into his 90s. In addition to honoring Dr. Larner’s memory, the goal of this lectureship is to highlight exciting new advances in an area that held great interest for him: the pervasive role of metabolism/cell signaling in human disease.

About this year's speaker:

Hosted by Thurl Harris and Michelle Bland, Michael Murphy is a Professor of Mitochondrial Redox Biology and Programme Leader at the MRC Mitochondrial Biology Unit at the University of Cambridge, UK

Dr. Murphy's Research Interests-

Mitochondrial dysfunction

Reactive oxygen species (ROS) produced by mitochondria cause oxidative damage that impairs the ability of mitochondria to make ATP and to carry out their metabolic functions. They may participate also in cellular redox signalling pathways.

One important aspect of our work is to investigate how oxidative damage to mitochondria contributes to human pathologies. We have worked out a way of targeting small bioactive molecules, such as antioxidants, to mitochondria in order to counter the effects of ROS and to examine the effects of doing so at cellular and whole animal levels. The bioactive molecule is attached chemically to a lipophilic cation such triphenylphosphonium. These cations accumulate selectively, first in the cytosol, driven by the plasma membrane potential, and then several-hundred fold in the matrix of mitochondria, driven by the membrane potential across the inner membrane.

A second important aspect is to determine whether and how mitochondrial ROS alters the activities of proteins in putative signalling and protective pathways by reversibly modifying the redox state of critical protein thiols in mitochondria. We use a range of free radical and proteomic approaches to identify the proteins involved, and to identify the cysteine residues and any redox modifications.

Finally, we take this information and use it to rationally design potential therapies for diseases that arise from mitochondria dysfunction. Currently our main focus for therapy is the ischaemia/reperfusion injury that arises from stroke and heart attack.

URL:
http://www.mrc-mbu.cam.ac.uk/people/mike-murphy
isCME:
No
speakers:
Michael Murphy, PhD, Professor of Mitochondrial Redox Biology and Program Director, MRC Mitochondrial Biology Unit, University of Cambridge, UK
registration:
No registration is necessary
contact:
Antoinette Reid Pharmacology 434-924-1919 adw2n@virginia.edu
Attachments:
Michael Murphy_LectureFlyerTabloid.pdf


Find Events by Date:

< November 2019 >
S M T W T F S
1 2
3 4 5 6 7 8 9
10 11 12 13 14 15 16
17 18 19 20 21 22 23
24 25 26 27 28 29 30

Refine View By:

Department:
Administration Administrator Development Admissions Anesthesiology Animal Care and Use Asthma, Allergy & Immunology Basic Science Departments Biochemistry, Molecular Biology and Genetics Biodefense Training Biology Biomedical Sciences Graduate Program Biomolecular Research Biophysics Graduate Program Biotechnology Training Program Cancer Center Cancer Center Research Program Events Cancer Center Seminar Series Cardiovascular Medicine Cardiovascular Research Center Carter Immunology Center Celebration Committee Cell Biology Cell and Developmental Biology Graduate Program Cell and Molecular Biology Graduate Program Center for Appreciative Practice Center for Cell Signaling Center for Comparative Medicine Center for Global Health Center for Health Humanities and Ethics Center for Improving Minority Health Center for Membrane and Cell Physiology Center for Public Health Genomics Center for Research in Reproduction Child Health Research Center Clinical Departments Clinical Trials Office Community Service Continuing Medical Education Department of Medicine Dermatology Diabetes Center Education Emergency Medicine Endocrinology & Metabolism Faculty Development Family Medicine Gastroenterology & Hepatology General Clinical Research Center General Medicine, Geriatrics & Palliative Care Go Girls Graduate Biosciences Society Graduate Programs Office Hematology & Oncology Infectious Diseases Infectious Diseases & International Health Infectious Diseases Training Program Journal Club LCME M.D./Ph.D. Program MSTP Medical Education Microbiology, Immunology and infectious Diseases Graduate Program Microbiology, Immunology, and Cancer Biology Molecular Cell and Developmental Biology Molecular Medicine Graduate Program Molecular Physiology & Biophysics Nephrology; Center for Immunity, Inflammation & Regenerative Medicine Neurology Neuroscience Neuroscience Graduate Program OB / Gyn Office of Research Core Administration Office of the Dean Ophthalmology Orthopaedic Surgery Otolaryngology Pathology Patient Care Pediatrics Pediatrics: GME Pharmacology Physical Medicine and Rehabilitation Psychiatry and Neurobehavioral Sciences Public Health Sciences Pulmonary & Critical Care Radiation Oncology Radiology Research Research-Office Rheumatology School of Medicine Stress Reduction Structural, Computational Biology Surgery Urology Women in Medicine Network

Type of Event:
Announcements Blood Drive Class Concert Conference Continuing Medical Education Education Offerings Exhibit Faculty Meeting FEAP Festival Forum Fundraiser Grand Rounds Immunization Interfaith Services Lecture Medical Center Hour Miscellaneous Open House Orientation Race/Walk Reception Recruiting Event Screening Seminar Support Group Symposium

Audience:
Employees Everyone Faculty Nurses Patients Students

CME:
No Yes, credit available Yes, no credit


Calendars: