Thu26

09:30 AM

day:
Thursday
date:
10/26/2017
time:
9:30 AM - 10:30 AM
event:
"Mechanisms and Function of Polyploidy in the Liver" by Andrew Duncan
location:
Pinn Hall 1-17
type:
Seminar
department:
Pharmacology
audience:
Faculty Students
details:
Hosted by Michelle Bland , Andrew W. Duncan, Phd, is an Assistant Professor of Pathology at the University of Pittsburg

Research Interests:

Research in the Duncan lab focuses on liver development, homeostasis and regeneration. Polyploidy is a defining feature of the adult liver. Hepatocytes are either mononucleated or binucleated, and ploidy is determined by the number of nuclei per cell as well as the ploidy of each nucleus. Although hepatic polyploidy has been described for well over 100 years, the functional role of hepatic polyploidization is unclear. Dr. Duncan's lab recently showed that regenerating polyploid hepatocytes undergo specialized cell divisions to form aneuploid daughter cells, generating a high degree of genetic diversity within the liver. Moreover, in rodent models, chromosome-specific aneuploid hepatocytes were shown to play a specialized role in liver regeneration, promoting adaptation and resistance to different forms of chronic liver injury.
URL:
http://path.upmc.edu/personnel/Faculty/duncan.htm
isCME:
No
speakers:
Andrew W. Duncan, Assistant Professor of Pathology, University of Pittsburgh, Pittsburgh, PA
registration:
No registration is necessary
contact:
Antoinette Reid Pharmacology 434-924-1919 adw2n@Virginia.EDU

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