Mon17

12:00 PM

day:
Monday
date:
12/17/2012
time:
12:00 PM - 1:00 PM
event:
CVRC Seminar, Dr. Pooneh Bagher , "Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events and IKCa channels reducing arteriolar tone"
location:
MR5 1005
type:
Seminar
department:
Cardiovascular Research Center
audience:
Employees Everyone Faculty Nurses Patients Students
details:
Endothelial cell, Ca2+-activated K channels (SKCa and IKCa channels) generate hyperpolarization that passes to the adjacent vascular smooth muscle cells to cause vasodilation in small resistance arterioles. IKCa channels expressed within endothelial cell projections toward the SMCs are activated by spontaneous Ca2+ events (Ca2+ puffs/pulsars). TRPV4 channels also cluster within this microdomain and are selectively activated at low intravascular pressure resulting in activation of endothelial cell IKCa channels and vasodilation, reducing the myogenic tone that underpins tissue blood-flow autoregulation.
URL:
www.cvrc.virginia.edu/events
isCME:
No
speakers:
Pooneh Bagher, Ph.D., Research Associate, Department of Pharmacology, University of Oxford
registration:
No registration is necessary
contact:
Andrea McNeely CVRC 2-3792 alm6f@Virginia.EDU
Attachments:
Seminar flier.docx

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