Events Calendar - Legacy [x], Medical Center [x], School of Medicine [x]
Mon17
12:00 PM
- day:
- Monday
- date:
- 12/17/2012
- time:
- 12:00 PM - 1:00 PM
- event:
- CVRC Seminar, Dr. Pooneh Bagher , "Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events and IKCa channels reducing arteriolar tone"
- location:
- MR5 1005
- type:
- Seminar
- department:
- Cardiovascular Research Center
- audience:
- Employees Everyone Faculty Nurses Patients Students
- details:
- Endothelial cell, Ca2+-activated K channels (SKCa and IKCa channels) generate hyperpolarization that passes to the adjacent vascular smooth muscle cells to cause vasodilation in small resistance arterioles. IKCa channels expressed within endothelial cell projections toward the SMCs are activated by spontaneous Ca2+ events (Ca2+ puffs/pulsars). TRPV4 channels also cluster within this microdomain and are selectively activated at low intravascular pressure resulting in activation of endothelial cell IKCa channels and vasodilation, reducing the myogenic tone that underpins tissue blood-flow autoregulation.
- URL:
- www.cvrc.virginia.edu/events
- isCME:
- No
- speakers:
- Pooneh Bagher, Ph.D., Research Associate, Department of Pharmacology, University of Oxford
- registration:
- No registration is necessary
- contact:
- Andrea McNeely CVRC 2-3792 alm6f@Virginia.EDU