Wed15

10:00 AM

day:
Wednesday
date:
03/15/2017
time:
10:00 AM - 11:00 AM
event:
"The Novel Role of Complement Cascade and Bioactive Phosphosphingolipids in Trafficking of Hematopoietic Stem Cells" by Mariusz Ratajczak
location:
Pinn Hall Rm. 5023
type:
Seminar
department:
Pharmacology
audience:
Faculty Students
details:
Hosted by Kevin Lynch, Mariusz Z. Ratajczak is the Professor of Department of Medicine at the University of Louisville School of Medicine and the Director of Stem Cell Program, James Graham Brown Cancer Center Stella and Henry Hoenig Endowed Chair in Cancer Biology. He is an Associate Member of Bone Marrow Transplant Program, University of Louisville School of Medicine and an Associate Member of the Department of Immunology and Microbiology, University of Louisville School of Medicine.

Dr. Ratajczak is an internationally known specialist in the field of adult stem cell biology. His 2005 discovery of embryonic-like stem cells in adult bone marrow tissues has the potential to revolutionize the field of regenerative medicine. This discovery may lead to new treatments for cancer, heart disease, eye disease, diabetes and neurodegenerative disorders. Dr. Ratajczak is also known from his work on novel mechanisms of mobilization and homing of stem cells, biological role of extracellular microvesicles and molecular mechanisms of cancer metastasis.

1. The role of developmentally early stem cells isolated from the adult tissues in regeneration. Identification of new mechanisms responsible for tissue/organ regeneration. Dr. Ratajczak developed a concept of circulating small pluripotent very small embryonic-like stem cells (VSELs) and is developing new strategies to isolate those cells from bone marrow, mobilized peripheral blood, cord blood and peripheral tissues.

2. The role of complement in stem cell homing/mobilization. Another area of investigations in Dr. Ratajczak’s laboratory is to elucidate the role of complement proteins in regulating human hematopoiesis. Dr. Ratajczak’s group identified a novel role of C3 complement cleavage fragments modulate the SDF-1-CXCR4 axis and thus play an important role in retaining human CXCR4+ hematopoietic stem cells in the bone marrow. Dr. Ratajczak also observed that antagonists of C3a receptor enhance G-CSF-mediated mobilization of hematopoietic stem cells into peripheral blood. This strategy could be explored in vivo as a new strategy to mobilize the so called “poor mobilizers”.

3. The role of bioactive lipids in stem cell homing/mobilization and cancer metastasis. Dr. Ratajczak’s laboratory is to elucidate the role of sphingosine-1 phosphate and ceramid-1 phosphate in regulating normal human hematopoiesis and directing mobilization and homing of various BM-derived adult stem cells. His group pioneered this field. In parallel his group is studying effect of bioactive lipids in cancer metastasis.

4. Biological effects of microvesciles and exosomes. Dr. Ratajczak’s laboratory is studying the role of membrane derived microparticles shed from the eukaryotic cells and their role in various biological processes. Recently, microvesicles, isolated from embryonic stem cells, were used by his group to improve ex vivo expansion and survival of hematopoietic stem/progenitor cells. He is also interested in the role of microvesicles in the progression of cancer. He found that platelet derived microvesicles may regulate metastatic behavior of cancer cells and for a first time described that they play a novel role in horizontal transfer mRNA and miRNA between the cells.

https://browncancercenter.louisville.edu/cancer-research/mariusz-z.-ratajczak-md-phd-dsci-dhc
URL:
isCME:
No
speakers:
Mariusz Z. Ratajczak, MD, PhD, "The Novel Role of Complement Cascade and Bioactive Phosphosphingolipids in Trafficking of Hematopoietic Stem Cells"
registration:
No registration is necessary
contact:
Antoinette Reid Pharmacology (434)924-1919 adw2n@Virginia.EDU
Attachments:
SeminarNotice_Mariusz Ratajczak.docx.pdf
day:
Wednesday
date:
03/15/2017
time:
12:00 PM - 1:00 PM
event:
BMG Faculty Recruitment Candidate: Dr. Mahoko Kai, John Hopkins University "Role of intrinisically disordered proteins in DSB repair"
location:
Pinn Hall Room 1014
type:
Seminar
department:
Biochemistry, Molecular Biology and Genetics
audience:
Everyone
details:
isCME:
No
registration:
No registration is necessary
contact:
Nancy Rush Biochemistry 3-0087 nr9b@Virginia.EDU
day:
Wednesday
date:
03/15/2017
time:
12:00 PM - 1:00 PM
event:
Medicine Grand Rounds | W. Michael Scheld, MD: "Ticks, Lice and Mites, and the Diseases They Transmit"
location:
Pinn Hall auditorium (formerly Jordan Hall), 1-5
type:
Grand Rounds
department:
Department of Medicine
audience:
Everyone
details:
URL:
https://med.virginia.edu/dom/education/professional-education/medicine-grand-rounds/
isCME:
Yes, credit available
speakers:
W. Michael Scheld, MD, is Professor of Medicine in the UVA Division of Infectious Diseases and International Health, Department of Medicine.
registration:
No registration is necessary
AJB9FA@virginia.edu
contact:
Tony Brinkman Medicine AJB9FA@virginia.edu
day:
Wednesday
date:
03/15/2017
time:
12:30 PM - 1:30 PM
event:
Eros And Illness
location:
Pinn Hall Conference Center Auditorium
type:
Medical Center Hour
department:
Center for Biomedical Ethics & Humanities
audience:
Everyone
details:
A John F. Anderson Memorial Lecture
isCME:
Yes, credit available
speakers:
David B. Morris PhD, University Professor Emeritus, UVA, Richmond VA
registration:
No registration is necessary
contact:
Charlene Kaufman CMK2B@hscmail.mcc.virginia.edu
day:
Wednesday
date:
03/15/2017
time:
1:00 PM - 2:00 PM
event:
Adaptive Evolution of the FADS Cluster and Polyunsaturated Fatty Acid Metabolism in the era of Precision Medicine
location:
Pinn 1-17 (formerly Jordan)
type:
Seminar
department:
Center for Public Health Genomics
audience:
details:
The Center for Public Health Genomics presents the Genome Sciences Seminar Series (GS3) in both Fall and Spring semesters each Wednesday from 1-2 pm in Pinn 1-17. An outstanding slate of speakers will discuss their cutting-edge research in areas such as systems biology, epigenetics and the genetic analysis of complex disease.
isCME:
No
speakers:
Rasika Mathias, ScD, Johns Hopkins University
registration:
No registration is necessary
contact:
Elizabeth Mollica Center for Public Health Genomics emm3w@virginia.edu
day:
Wednesday
date:
03/15/2017
time:
4:00 PM - 5:00 PM
event:
MIC Student Seminar
location:
Pinn Hall 1-17 4-5PM
type:
Seminar
department:
Microbiology, Immunology, and Cancer Biology
audience:
details:
Stephanie Ragland, Alison Criss Laboratory "Lysozyme resistance in Neisseria gonorrhoeae contributes to bacterial survival in the presence of human neutrophils"
Adam Greene, James Casanova Laboratory “Salmonella typhimurium manipulates cholesterol trafficking in macrophages via suppression of the host cholesterol transport protein ABCA1"
isCME:
No
speakers:
Stephanie Ragland, Alison Criss Laboratory Adam Greene, Casanova Laboratory
registration:
No registration is necessary
contact:
Regina Seitz 4-5111 rmm5m@hscmail.mcc.virginia.edu

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