Events Calendar - School of Medicine [x]

Tue7

07:00 AM

day:
Tuesday
date:
02/07/2012
time:
7:00 AM - 8:00 AM
event:
Cardiology Interventional Teaching Conference
location:
Bustle Conference Rooms
type:
Conference
department:
Cardiovascular Medicine Department of Medicine
audience:
Faculty Nurses Students
details:
isCME:
No
registration:
No registration is necessary
contact:
Anne Shipe Cardiology 434-924-9001 ars3g@virginia.edu
day:
Tuesday
date:
02/07/2012
time:
12:00 PM - 1:00 PM
event:
Endocrinology Grand Rounds
location:
type:
Grand Rounds
department:
Department of Medicine Endocrinology & Metabolism
audience:
Faculty Nurses Students
details:
Stateof-the-art lectures by internal and external speakers on clinical and scientific topics. Each fellow also presents a clinical and/or research topic once a year.
isCME:
No
registration:
No registration is necessary
contact:
Sandy Sutton Endocrinology 434-243-8482 cls8se@virginia.edu
day:
Tuesday
date:
02/07/2012
time:
12:00 PM - 1:00 PM
event:
Pulmonary Core Curriculum Conference
location:
West Complex - DOM Library Room 6522
type:
Conference
department:
Department of Medicine Pulmonary & Critical Care
audience:
Faculty Students
details:
isCME:
No
speakers:
various
registration:
No registration is necessary
contact:
Whitney Lightfoot Pulmonary 434-924-1693 wml4t@hscmail.mcc.virginia.edu
day:
Tuesday
date:
02/07/2012
time:
12:00 PM - 1:00 PM
event:
CVRC Seminar, Dr. Julia Gorelik
location:
MR5 1005
type:
Seminar
department:
Cardiovascular Research Center
audience:
details:
Conventional physiological techniques for cardiac cells have attained important achievements during past decades. However, few of them resolve physiological processes at the nanoscale level in living cells. Scanning ion conductance microscopy (SICM) is a unique imaging technique that uses similar principles to the atomic force microscope, but with a pipette for the probe. The scanning technique enables simultaneous recording of high-resolution topography of cell surfaces, and cell surface fluorescence. The hybrid instrument also functions as a vastly improved patch clamp system (the "smart patch"). The method allows scanning of the surface of living cells noninvasively and enables measurement of cellular activities under more physiological conditions than is possible with other techniques.

Since the activity of various receptors and ion channels is highly organized in space and time , it is essential to correlate intracellur signalling with cell structures and subcellular compartments. We describe and validate scanning ion conductance microscopy combined with conventional methods (FRET, patch-clamp, intercellular recording and optical mapping of impulse propagation ) as a new technique for cardiac cell physiology . Such hybrid technologies revealed i) functional localization of beta –adrenergic receptors; ii) location of ionic currents and membrane potential and iii) dynamics of intercellular impulse propagation in cardiac cells.

In addition, we recently developed a SICM modification permitting to apply quantified positive and negative force at defined positions to the surface of cells. With this method hydrostatic pressure (0.1–150 kPa) is applied through a pipette. To prevent any surface contact, or contamination of the pipette, the distance between the pipette and cell surface is kept constant using ion conductance-based distance feedback, allowing fast and repeated measurements. Here we show that we can probe the local mechanical properties of living cells using increasing pressure, and hence measure the nanomechanical properties of the cell membrane and the underlying cytoskeleton in a variety of cells (cardiomyocytes and vascular endothelial cells) and tissue (cardiac valve and aorta) Because the cell surface can first be imaged without pressure, it is possible to relate the mechanical properties to the local cell topography. This method is well suited to probe the nanomechanical properties and mechanosensitivity of living cells.
URL:
http://www.cvrc.virginia.edu/events
isCME:
No
speakers:
Julia Gorelik, PhD, National Heart and Lung Institute, Imperial College London
registration:
No registration is necessary
contact:
Andrea McNeely CVRC 2-3792 alm6f@Virginia.EDU
day:
Tuesday
date:
02/07/2012
time:
1:00 PM - 2:00 PM
event:
Gastroenterology Pathophysiology
location:
DHC Endo Classroom
type:
Conference
department:
Department of Medicine Gastroenterology & Hepatology
audience:
details:
isCME:
No
registration:
No registration is necessary
contact:
Amy Harris Gastroenterology 434-243-6400 amyharris@virginia.edu
day:
Tuesday
date:
02/07/2012
time:
1:00 PM - 2:00 PM
event:
Pulmonary Tumor Board
location:
type:
Miscellaneous
department:
Department of Medicine Pulmonary & Critical Care
audience:
details:
isCME:
No
registration:
No registration is necessary
contact:
Whitney Lightfoot Pulmonary Medicine 434-924-1693 wml4t@hscmail.mcc.virginia.edu
day:
Tuesday
date:
02/07/2012
time:
1:00 PM - 2:00 PM
event:
Endocrinology Clinical Case Conference
location:
type:
Conference
department:
Department of Medicine Endocrinology & Metabolism
audience:
Faculty Students
details:
Fellows present 2-3 clinical cases to the clinical faculty. This is a teaching conference where pathophysiology, diagnostic considerations (e.g., technical aspects of hormone assays), approaches to management, and relevant literature are routinely discussed.
isCME:
No
registration:
No registration is necessary
contact:
Sandy Sutton Endocrinology 434-243-8482 cls8se@virginia.edu
day:
Tuesday
date:
02/07/2012
time:
2:00 PM - 3:00 PM
event:
Endocrinology Fellows Clinical Lecture Series
location:
type:
Lecture
department:
Department of Medicine Endocrinology & Metabolism
audience:
details:
Faculty give didactic lectures on a wide array of clinical topics.
isCME:
No
registration:
No registration is necessary
contact:
Sandy Sutton Endocrinology 434-243-8482 cls8se@virginia.edu
day:
Tuesday
date:
02/07/2012
time:
4:00 PM - 5:00 PM
event:
Pulmonary Literature Review
location:
West Complex - DOM Library Room 6522
type:
Conference Seminar
department:
Department of Medicine Pulmonary & Critical Care
audience:
Faculty Students
details:
isCME:
No
registration:
No registration is necessary
contact:
Whitney Lightfoot Pulmonary Medicine 434-924-1693 wml4t@hscmail.mcc.virginia.edu
day:
Tuesday
date:
02/07/2012
time:
4:00 PM - 5:00 PM
event:
Tuesday Anesthesiology Resident Seminar
location:
OR classroom
type:
Conference
department:
Anesthesiology
audience:
details:
Critical Incident Conference
isCME:
No
speakers:
Julie L. Huffmyer, M.D.
registration:
No registration is necessary
contact:
Patty Jenkins Anesthesiology 924-9509 PPJ@hscmail.mcc.virginia.edu

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