Thu14

09:30 AM

day:
Thursday
date:
09/14/2017
time:
9:30 AM - 10:30 AM
event:
"Initiation and Regulation of Innate Immunity" by Jonathan Kagan
location:
Pinn Hall 1-17
type:
Seminar
department:
Pharmacology
audience:
Faculty Students
details:
Hosted by Bimal Desai, Jonathan Kagan, Phd, is an Associate Professor of Pediatrics, Harvard Medical School; Shwachman Chair in Gastroenterology and Staff Scientist, Boston Children's Hospital

Research Focus Area: Signal transduction pathways of the immune system

Ancient signaling pathways lie at the base of the initiation of immunity, serving to transmit signals from Pattern Recognition Receptors (PRRs) to trigger the activation of anti-microbial defenses. All PRRs, which evolved to detect potentially pathogenic microorganisms, operate by following two cellular rules: 1) these receptors must activate cytosolic signaling with extremely fast kinetics (within seconds of ligand binding) 2) these receptors must survey multiple cellular compartments, yet still recruit a common set of signaling proteins to each location. How does a signaling network develop that has properties of near immediate responsiveness, yet the flexibility to signal from multiple locations?

While most research on immune signal transduction focuses on the effector functions of signaling proteins, we are interested in understanding how these proteins are organized in the cytosol to promote both rapid responses and the flexibility of signaling locale. Using the Toll-like Receptor (TLR) family of PRRs as a model, we seek to explain the operation of cytosolic signaling proteins that function in immune defense.

TLRs promote the initiation of both innate and adaptive immunity to infectious microorganisms and as such, the regulation of TLR signaling lies at the base of important issues in human health, such as the generation of effective vaccines, autoimmunity, and even cancer.
Understanding the fundamental cellular principles that control TLR signaling will likely reveal important insight into these problems and will open up new possibilities for treatment of common ailments that affect humanity.

Current projects in the lab focus on addressing the following problems:

1. How are TLR signaling proteins delivered to the appropriate cellular locations to promote signal transduction?

2. What are the biochemical properties of TLR-induced signaling complexes?

3. How does the innate immune response deal with commensal bacteria in the intestine?


URL:
http://kaganlab.com/index.html
isCME:
No
speakers:
Jonathan Kagan, PhD, Associate Professor, Pediatrics, Harvard Medical School; Shwachman Chair in Gastroenterology and Staff Scientist, Division of Gastroenterology, Boston Children's Hospital
registration:
No registration is necessary
contact:
Antoinette Reid Pharmacology (434)924-1919 adw2n@Virginia.EDU
Attachments:
SeminarNotice_JonathanKagan.pdf
day:
Thursday
date:
09/14/2017
time:
12:00 PM - 1:00 PM
event:
BMG Seminar Dr. Narendara Wajapeye, "Metabolic Disruptions and Their Role in Driving Human Diseases"
location:
Pinn Hall 1017
type:
Seminar
department:
Biochemistry, Molecular Biology and Genetics
audience:
Everyone
details:
isCME:
No
registration:
No registration is necessary
contact:
Nancy Rush Biochemistry 3-0087 nr9b@Virginia.EDU
day:
Thursday
date:
09/14/2017
time:
5:30 PM - 6:30 PM
event:
Go Girls! Fitness Support Group
location:
UVA Battle Building OR Orange Pediatrics
type:
Class
department:
Go Girls
audience:
Everyone
details:
Go Girls! is a fun dance-based fitness and education program for girls ages 7-21. Our group meets every week to exercise in a fun environment, make new friends, and support each other in wellness goals. We participate in 45 minutes of dance fun followed by a brief wellness discussion. Go Girls! is free for girls ages 7-21 & female family and friends!

Join us at The Battle Building at the University of Virginia Children's Hospital, 1204 West Main St, Charlottesville, VA.

OR, join us at Orange Pediatrics - Orange Medical Center, 661 University Lane, Suite A, Orange, VA

Free parking is provided for Go Girls! participants in the 11th street garage. After 5pm use push button/video phone for building access on the W. Main St. entrance or the 3rd floor parking garage entrance (level C). Please bring your parking garage ticket in and get it validated.

Classes are also held on Mondays from 5:45 - 6:45 p.m. at UVA Primary Care Zion Crossroads - UVA Medical Park Zion Crossroads, 1015 Spring Creek Parkway, Zion Crossroads, VA 22942











URL:
http://gogirls.virginia.edu
isCME:
No
registration:
No registration is necessary
http://www.gogirls.virginia.edu/programs/registration
contact:
Anna King Akk8n@hscmail.mcc.virginia.edu
day:
Thursday
date:
09/14/2017
time:
5:30 PM - 7:30 PM
event:
WIMN's "The Business of Medicine" series - Featuring DOM Chair Mitch Rosner, MD, and Russ Manley, COO
location:
Pinn Hall, 2ABC
type:
Forum
department:
Women in Medicine Network
audience:
details:
Want to learn more about the business side of the Department of Medicine? DOM chair Mitch Rosner, MD, and COO Russ Manley will review the department business model and discuss issues particularly pertinent to women in DOM.
URL:
https://med.virginia.edu/dom/education/women-in-internal-medicine-network/
isCME:
No
speakers:
Mitch Rosner, MD, and Russ Manley
registration:
No registration is necessary
RSVP to RWomeninMedicineNetwork@hscmail.mcc.virginia.edu
contact:
Jane Perry JLP6F@hscmail.mcc.virginia.edu

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